ArticleScientific reports2017
ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.
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Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
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Who cites it
45 citing papers in PubMed, 59 citations in OpenAlex.
- Traumatic Brain Injury and the Road to Alzheimer's Disease.Biomedicines · 2026Review
- Chronic traumatic encephalopathy: A devastating legacy of repetitive concussion.Neurobiology of disease · 2026Review
- Neuron-Derived Extracellular Vesicles: Emerging Regulators in Central Nervous System Disease Progression.Molecular neurobiology · 2025Review
- Gut microbiota diversity and metabolomics analysis of curcumin's alleviation of abdominal aortic aneurysm progression.Molecular and cellular biochemistry · 2025Article
- Sex and Genotype Affect Mouse Hippocampal Gene Expression in Response to Blast-Induced Traumatic Brain Injury.Molecular neurobiology · 2025Article
- Functional hydrogel for modulating lipid droplets and neuroinflammation in head injury.Advanced functional materials · 2025Article
- Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies.Current protein & peptide science · 2025Review
- Glycerophospholipid dysregulation after traumatic brain injury.Neurochemistry international · 2024Review
- Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain.Experimental neurology · 2024Article
- The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma.International journal of molecular sciences · 2024Review
- Dementia and Depression Among Older Adults Following Traumatic Brain Injury.Advances in neurobiology · 2024Review
- Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus.Molecular psychiatry · 2023Article
- Synaptojanin 1 Modulates Functional Recovery After Incomplete Spinal Cord Injury in Male Apolipoprotein E Epsilon 4 Mice.Neurotrauma reports · 2023Article
- Neuroprotective Effects of Nanowired Delivery of Cerebrolysin with Mesenchymal Stem Cells and Monoclonal Antibodies to Neuronal Nitric Oxide Synthase in Brain Pathology Following Alzheimer's Disease Exacerbated by Concussive Head Injury.Advances in neurobiology · 2023Review
- APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases.Molecular neurodegeneration · 2022Review
- Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases.International journal of molecular sciences · 2022Review
- TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target.Molecular neurodegeneration · 2022Review
- Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.Molecular psychiatry · 2021Article
- MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis.Molecular psychiatry · 2021Article
- Region-Specific Differences in the Apoe4-dependent Response to Focal Brain Injury.Experimental neurobiology · 2021Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Jiqing CaoJames J. Peters VA Medical Center, Neurology Service, Bronx, NY, 10468, USA.
Farida El GaamouchJames J. Peters VA Medical Center, Neurology Service, Bronx, NY, 10468, USA.
James S MeabonVeterans Affairs Medical Center (VAPSHCS), Mental Illness Research and Educational Clinical Center, Seattle, 98108, WA, USA.
Kole D MeekerVeterans Affairs Medical Center (VAPSHCS), Mental Illness Research and Educational Clinical Center, Seattle, 98108, WA, USA.
Li ZhuJames J. Peters VA Medical Center, Neurology Service, Bronx, NY, 10468, USA.
Margaret B ZhongDepartment of Neurology, Alzheimer Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
John BendikDepartment of Neurology, Alzheimer Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Gregory ElderJames J. Peters VA Medical Center, Neurology Service, Bronx, NY, 10468, USA.
Ping JingThe Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430021, China.
Jiahong XiaThe Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430021, China.
Wenjie LuoBrain and Mind Research Institute, Weill Cornell Medical College, New York, NY, 10065, USA.
David G CookVeteran Affairs Medical Center (VAPSHCS), Geriatric Research Education and Clinical Center, Seattle, 98108, WA, USA. dgcook@u.washington.edu.
Dongming CaiJames J. Peters VA Medical Center, Neurology Service, Bronx, NY, 10468, USA. dongming.cai@mssm.edu.ORCID 0000-0002-0601-6826
James J. Peters VA Medical Center · USUniversity of Washington · USCentral Hospital of Wuhan · CNIcahn School of Medicine at Mount Sinai · USCornell University · US
Funding
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MPharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6MMolecular Characterization and Validation of Gender Differences in Alzheimers Disease PathogenesisRF1AG054014 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DONGMING, ZHANG, BIN · 2016 to 2016
$4.2MCharacterization of ApoE4 Induced Phospholipid Dysregulation in AD PathogenesisR01AG048923 · NIA · UNIVERSITY OF MINNESOTA · PI CAI, DONGMING · 2015 to 2025
$3.1MNovel small molecules targeting brain phospholipid dysregulation in ADI01RX002290 · VA · JAMES J PETERS VA MEDICAL CENTER · PI CAI, DONGMING · 2018 to 2022
–Development of Novel Therapies for AD Targeting Abeta ClearanceI21RX001558 · VA · JAMES J PETERS VA MEDICAL CENTER · PI CAI, DONGMING · 2015 to 2015
–MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease PathogenesisI01BX003380 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI CAI, DONGMING · 2017 to 2025
–BLRD VA I01 BX003380NIA NIH HHS R01 AG048923NIA NIH HHS RF1 AG054014NIDDK NIH HHS P30 DK017047RRD VA I01 RX002290RRD VA I21 RX001558
Abstract
The apolipoprotein E4 (ApoE4) genotype combines with traumatic brain injury (TBI) to increase the risk of developing Alzheimer's Disease (AD). However, the underlying mechanism(s) is not well-understood. We found that after exposure to repetitive blast-induced TBI, phosphoinositol biphosphate (PIP
Indexed as
AnimalsApolipoprotein E3Apolipoprotein E4BrainBrain Injuries, TraumaticCell LineHippocampusMiceMice, TransgenicPhosphoinositide 5-PhosphatasesPhospholipidsPhosphoric Monoester HydrolasesPhosphorylationtau ProteinsApolipoprotein E3Apolipoprotein E4Phosphoinositide 5-PhosphatasesPhospholipidsPhosphoric Monoester Hydrolasestau Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.