ArticleScientific reports2017
Inflexible neurobiological signatures precede atypical development in infants at high risk for autism.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Sleep on it: exploring the psychology of sleep amidst contemporary challenges.Scientific reports · 2024Article
- Sensorimotor variability distinguishes early features of cognition in toddlers with autism.iScience · 2024Article
- Neurobiology of cognitive abilities in early childhood autism.JCPP advances · 2024Article
- Spatiotemporal patterns of spontaneous movement in neonates are significantly linked to risk of autism spectrum disorders at 18 months old.Scientific reports · 2023Article
- Newborn Auditory Brainstem Responses in Children with Developmental Disabilities.Journal of autism and developmental disorders · 2023Article
- The importance of low IQ to early diagnosis of autism.Autism research : official journal of the International Society for Autism Research · 2023Article
- Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms.Sleep medicine reviews · 2022Review
- Behavioural Differences in Sensorimotor Profiles: A Comparison of Preschool-Aged Children with Sensory Processing Disorder and Autism Spectrum Disorders.Children (Basel, Switzerland) · 2022Article
- Genetic vulnerability of exposures to antenatal maternal treatments in 1- to 2-month-old infants.Infancy : the official journal of the International Society on Infant Studies · 2021Article
- Hyper-Reactivity to Salience Limits Social Interaction Among Infants Born Pre-term and Infant Siblings of Children With ASD.Frontiers in psychiatry · 2021Article
- Spatiotemporal organization of myoclonic twitching in sleeping human infants.Developmental psychobiology · 2020Article
- THE DEVELOPING BRAIN REVEALED DURING SLEEP.Current opinion in physiology · 2020Article
- Markerless Measurement and Evaluation of General Movements in Infants.Scientific reports · 2020Article
- Observational
- Atypical body movements during night in young children with autism spectrum disorder: a pilot study.Scientific reports · 2019Article
- The Apgar paradox.European journal of epidemiology · 2019Article
- Pre-emptive Intervention for Autism Spectrum Disorder: Theoretical Foundations and Clinical Translation.Frontiers in integrative neuroscience · 2019Review
- Reduced structural complexity of the right cerebellar cortex in male children with autism spectrum disorder.PloS one · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variability in neurobiological signatures is ubiquitous in early life but the link to adverse developmental milestones in humans is unknown. We examined how levels of signal and noise in movement signatures during the 1st year of life constrain early development in 71 healthy typically developing infants, either at High or Low familial Risk (HR or LR, respectively) for developing Autism Spectrum Disorders (ASD). Delays in early learning developmental trajectories in HR infants (validated in an analysis of 1,445 infants from representative infant-sibling studies) were predicted by worse stochastic patterns in their spontaneous head movements as early as 1-2 months after birth, relative to HR infants who showed more rapid developmental progress, as well as relative to all LR infants. While LR 1-2 mo-old infants' movements were significantly different during a language listening task compared to during sleep, HR infants' movements were more similar during both conditions, a striking lack of diversity that reveals context-inflexible experience of ambient information. Contrary to expectation, it is not the level of variability per se that is particularly detrimental in early life. Rather, inflexible sensorimotor systems and/or atypical transition between behavioral states may interfere with the establishment of capacity to extract structure and important cues from sensory input at birth, preceding and contributing to an atypical brain developmental trajectory in toddlerhood.
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