ArticleScientific reports2017
A unique case of human Zika virus infection in association with severe liver injury and coagulation disorders.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review.F1000Research · 2019Pooled it
- Unveiling the cardiovascular impact of Zika Virus: Myocardial injury, prothrombotic state, and oxidative stress in immunocompetent mice.PLoS neglected tropical diseases · 2025Article
- Article
- Zika virus capsid protein closed structure modulates binding to host lipid systems.Protein science : a publication of the Protein Society · 2024Article
- Viruses and thrombocytopenia.Heliyon · 2024Review
- Implications of LDH in patients with coronavirus disease 2019 pneumonia.Frontiers in cellular and infection microbiology · 2023Article
- The Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients.Inflammation · 2022Review
- Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities.European journal of immunology · 2022Review
- Article
- Thrombocytopenia in Virus Infections.Journal of clinical medicine · 2021Review
- Detection of Virus-Related Sequences Associated With Potential Etiologies of Hepatitis in Liver Tissue Samples From Rats, Mice, Shrews, and Bats.Frontiers in microbiology · 2021Article
- Antiviral anticoagulation.Research and practice in thrombosis and haemostasis · 2020Review
- Observational
- Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice.PLoS pathogens · 2020Article
- The Role of Emerging and Neglected Viruses in the Etiology of Hepatitis.Current infectious disease reports · 2019Review
- Zika virus in Vietnam, Laos, and Cambodia: are there health risks for travelers?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection.Journal of virology · 2019Article
- Simultaneous Coinfection of Macaques with Zika and Dengue Viruses Does not Enhance Acute Plasma Viremia but Leads to Activation of Monocyte Subsets and Biphasic Release of Pro-inflammatory Cytokines.Scientific reports · 2019Article
- Zika Virus Induced More Severe Inflammatory Response Than Dengue Virus in Chicken Embryonic Livers.Frontiers in microbiology · 2019Article
- Zika Virus Infection Induces Elevation of Tissue Factor Production and Apoptosis on Human Umbilical Vein Endothelial Cells.Frontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
absatrctZika virus (ZIKV) has caused major concern globally due to its rapid dissemination and close association with microcephaly in children and Gullian-Barr syndrome in adults. In this study, we identified a patient returned from Cambodia who experienced high fever, chill and myalgia. Lab tests discovered sign of severe liver injury including significantly elevated serum transaminases' level, decreased serum albumin level, and markedly increased levels of lactic dehydrogenase, alpha-hydroxybutyric dehydrogenase and creatine kinase in serum. Moreover, severe thrombocytopenia and altered blood levels of fibrinogen and fibrinogen degradation product were also observed, indicating the existence of clotting disorders. A ZIKV strain clustered into the Asian lineage was isolated from the patient's serum. When inoculated into suckling mice, this virus significantly retarded mouse body-weight gain and caused 70% mortality. Our results demonstrate a close association between ZIKV and severe liver injury and coagulation disorders and suggest that clinicians should be aware of compatible symptoms in patients and manage them accordingly.
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