Evidence map›Paper›PMID 28900037›Full record

ArticleThe Journal of biological chemistry2017

ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα.

David Gonzalez, Annouck Luyten, Boris Bartholdy, Qiling Zhou, Miroslava Kardosova, Alex Ebralidze, Kenneth D Swanson, Hanna S Radomska, Pu Zhang, Susumu S Kobayashi and 10 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 5 countries.

David GonzalezFrom the Cancer Science Institute, National University of Singapore, 117599 Singapore.
Annouck LuytenFrom the Cancer Science Institute, National University of Singapore, 117599 Singapore.
Boris Bartholdythe Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115.
Qiling ZhouFrom the Cancer Science Institute, National University of Singapore, 117599 Singapore.
Miroslava Kardosovathe Institute of Molecular Genetics of the ASCR, Prague 142 20, Czech Republic.
Alex Ebralidzethe Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115.
Kenneth D Swansonthe Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115.
Hanna S Radomskathe Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115.
Pu Zhangthe Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115.
Susumu S Kobayashithe Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115.
Robert S Welnerthe Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115.
Elena Levantinithe Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115.
Ulrich Steidlthe Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115.
Gilbert ChongFrom the Cancer Science Institute, National University of Singapore, 117599 Singapore.
Samuel CollombetFrom the Cancer Science Institute, National University of Singapore, 117599 Singapore.
Min Hee ChoiFrom the Cancer Science Institute, National University of Singapore, 117599 Singapore.
Alan D FriedmanThe Johns Hopkins University, Baltimore, Maryland 21231.
Linda M Scottthe The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.
Meritxell Alberich-Jordathe Institute of Molecular Genetics of the ASCR, Prague 142 20, Czech Republic, alberich@img.cas.cz.
Daniel G TenenFrom the Cancer Science Institute, National University of Singapore, 117599 Singapore, daniel.tenen@nus.edu.sg.
Harvard University · USNational University of Singapore · SGHarvard Stem Cell Institute · USCzech Academy of Sciences, Institute of Molecular Genetics · CZJohns Hopkins University · USNational Research Council · ITUniversity of Queensland · AU

Funding

TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David T Scadden · 2017 to 2026
$24.6M
Mechanisms of regulation by RNA in acute myeloid leukemiaR35CA197697 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TENEN, DANIEL G · 2015 to 2021
$7.1M
Overcoming resistance to tyrosine kinase inhibitors in lung cancerR01CA169259 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KOBAYASHI, SUSUMU · 2013 to 2018
$1.8M
Emergence of drug resistant mutations in lung cancerR21CA178301 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KOBAYASHI, SUSUMU · 2015 to 2016
$435k
NCCDPHP CDC HHS R01 DP000110NCI NIH HHS P01 CA066996NCI NIH HHS R01 CA169259NCI NIH HHS R21 CA178301NCI NIH HHS R35 CA197697NHLBI NIH HHS P01 HL131477
6 · The paper itself

Abstract

The transcription factor C/EBPα is essential for myeloid differentiation and is frequently dysregulated in acute myeloid leukemia. Although studied extensively, the precise regulation of its gene by upstream factors has remained largely elusive. Here, we investigated its transcriptional activation during myeloid differentiation. We identified an evolutionarily conserved octameric sequence, CCCAGCAG, ∼100 bases upstream of the

Indexed as

Promoter Regions, GeneticTranscriptional ActivationBase SequenceCCAAT-Enhancer-Binding Protein-alphaCell LineConserved SequenceGene Expression Regulation, DevelopmentalHematopoiesisHumansMyeloid CellsProtein BindingTrans-ActivatorsCCAAT-Enhancer-Binding Protein-alphaTrans-ActivatorsZNF143 protein, humanCCAAT-enhancer-binding protein (C/EBP)C/EBPalphagene regulationhematopoiesispromotertranscription factorZNF143

Identifiers

PMID28900037
PMCPMC5704476
OpenAlexW2754435174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.