Evidence map›Paper›PMID 28900026›Full record

ArticlemBio2017

Activity-Related Conformational Changes in d,d-Carboxypeptidases Revealed by

Nils Y Meiresonne, René van der Ploeg, Mark A Hink, Tanneke den Blaauwen

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Biofilm dispersal patterns revealed using far-red fluorogenic probes.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. TheInternational journal of molecular sciences · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Detection ofBio-protocol · 2019
    Article
  18. Article
  19. Review
  20. Superfolder mTurquoise2Molecular microbiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nils Y MeiresonneBacterial Cell Biology and Physiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-9184-4361
René van der PloegBacterial Cell Biology and Physiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-2490-9262
Mark A HinkMolecular Cytology and van Leeuwenhoek Centre for Advanced Microscopy, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Tanneke den BlaauwenBacterial Cell Biology and Physiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands t.denblaauwen@uva.nl.ORCID 0000-0002-5403-5597
University of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the mechanisms of β-lactam antibiotic resistance requires the activity of d,d-carboxypeptidases (d,d-CPases) involved in peptidoglycan (PG) synthesis, making them putative targets for new antibiotic development. The activity of PG-synthesizing enzymes is often correlated with their association with other proteins. The PG layer is maintained in the periplasm between the two membranes of the Gram-negative cell envelope. Because no methods existed to detect

Indexed as

CarboxypeptidasesEscherichia coliEscherichia coli ProteinsFluorescence Resonance Energy TransferLuminescent ProteinsPeptidoglycanPeriplasmProtein ConformationRed Fluorescent ProteinSerine-Type D-Ala-D-Ala CarboxypeptidaseCarboxypeptidasesDacC protein, E coliEscherichia coli ProteinsLuminescent ProteinsPBP5 protein, E coliPeptidoglycanRed Fluorescent ProteinSerine-Type D-Ala-D-Ala CarboxypeptidaseantibioticsFRETmCherrymNeonGreenPBP5PBP6aPBP6bperiplasmprotein interactions

Identifiers

PMID28900026
PMCPMC5596342
OpenAlexW2754686689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.