Evidence map›Paper›PMID 28900022›Full record

ArticlemBio2017

Binding of NAD

Jorge J Velarde, Maghnus O'Seaghdha, Buket Baddal, Benedicte Bastiat-Sempe, Michael R Wessels

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Tracing the recent evolution of Group AEmerging microbes & infections · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Clinical microbiology reviews · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Microorganisms · 2022
    Article
  11. Article
  12. Structure of the Streptococcus pyogenes NADJournal of bacteriology · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Nicotinamide Increases Intracellular NADFrontiers in microbiology · 2020
    Article
  17. Article
  18. Review
  19. Group AFrontiers in cellular and infection microbiology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jorge J VelardeDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Maghnus O'SeaghdhaDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Buket BaddalDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Benedicte Bastiat-SempeDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Michael R WesselsDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA Michael.Wessels@childrens.harvard.edu.
Harvard University · USBoston Children's Hospital · US

Funding

IMMUNE RESPONSE TO THE GROUP A STREPTOCOCCAL CAPSULER01AI029952 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI WESSELS, MICHAEL R · 1991 to 2019
$5.6M
Virulence mechanisms of group A streptococcal toxinsR01AI070926 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WESSELS, MICHAEL R · 2008 to 2011
$1.5M
Structure and Function Studies of LL-37 Binding to CsrS of Group A StreptococcusK08AI112823 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI VELARDE, JORGE J · 2016 to 2020
$939k
Virulence mechanisms of group A streptococcal toxinsR56AI070926 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WESSELS, MICHAEL R · 2014 to 2014
$440k
NIAID NIH HHS K08 AI112823NIAID NIH HHS R01 AI029952NIAID NIH HHS R01 AI070926NIAID NIH HHS R56 AI070926
6 · The paper itself

Abstract

The globally dominant, invasive M1T1 strain of group A

Indexed as

Bacterial ProteinsCells, CulturedCulture MediaCytotoxinsHumansKeratinocytesNAD+ NucleosidaseOperonPoint MutationProtein BindingProtein StabilityStreptococcal InfectionsStreptococcus pyogenesStreptolysinsVirulenceVirulence FactorsBacterial ProteinsCulture MediaCytotoxinsNAD+ Nucleosidasestreptolysin OStreptolysinsVirulence Factorscholesterol-dependent cytolysinNAD+-glycohydrolasepore-forming toxinsStreptococcus pyogenesstreptolysin O

Identifiers

PMID28900022
PMCPMC5596348
OpenAlexW2754256303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.