ArticleCirculation. Heart failure2017
Impact of Incident Heart Failure on Body Composition Over Time in the Health, Aging, and Body Composition Study Population.
Open access · bronzeAbstract readComparative StudyMulticenter Study
In one paragraph
Article in Circulation. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Cognition and Frailty in Patients With Heart Failure: A Systematic Review of the Association Between Frailty and Cognitive Impairment.Frontiers in psychiatry · 2021Pooled it
- Bone mineral density in patients with chronic heart failure: a meta-analysis.Clinical interventions in aging · 2018Pooled it
- Nothobranchius furzeri: a vertebrate model for studying cardiac aging and cellular senescence.npj aging · 2025Article
- Obesity, Metabolic Syndrome, and Obesity Paradox in Heart Failure: A Critical Evaluation.Current heart failure reports · 2024Review
- Reduced thoracic skeletal muscle size is associated with adverse outcomes in diabetes patients with heart failure and reduced ejection fraction: quantitative analysis of sarcopenia by using cardiac MRI.Cardiovascular diabetology · 2024Article
- The association between frailty and in-hospital mortality in critically ill patients with congestive heart failure: results from MIMIC-IV database.Frontiers in cardiovascular medicine · 2024Article
- Frailty alone and interactively with obesity predicts heart failure: Kuopio Ischaemic Heart Disease Risk Factor Study.ESC heart failure · 2023Article
- Prognostic Value of Spot Urinary Creatinine Concentration and Its Relationship with Body Composition Parameters in HF Patients.Biomedicines · 2023Article
- Association between changes in predicted body composition and occurrence of heart failure: a nationwide population study.Frontiers in endocrinology · 2023Article
- Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF.Frontiers in cardiovascular medicine · 2023Review
- Sarcopenia and Frailty in Heart Failure: Is There a Biomarker Signature?Current heart failure reports · 2022Review
- Prevalence of metabolic syndrome and associated factors among patients with chronic Chagas disease.PloS one · 2021Article
- Frailty Is Intertwined With Heart Failure: Mechanisms, Prevalence, Prognosis, Assessment, and Management.JACC. Heart failure · 2019Review
- Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future.Journal of the American College of Cardiology · 2018Review
- Body Mass Index and Heart Failure Mortality: More Is Less?JACC. Heart failure · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Daniel E FormanFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.). formand@pitt.edu.
Adam J SantanastoFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Robert BoudreauFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Tamara HarrisFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Alka M KanayaFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Suzanne SatterfieldFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Eleanor M SimonsickFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Javed ButlerFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Jorge R KizerFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Anne B NewmanFrom the Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System (D.E.F.), Department of Epidemiology, Center for Aging and Population Health (A.J.S.), Department of Epidemiology, Graduate School of Public Health (R.B.), and Epidemiology, Medicine, and Clinical and Translational Science Institute (A.B.N.), University of Pittsburgh, PA; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD (T.H.); Division of General Internal Medicine, University of California in San Francisco (A.M.K.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); Intramural Research Program, National Institute on Aging, Baltimore, MD (E.M.S.); Division of Cardiology, Stony Brook University, NY (J.B.); and Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY (J.R.K.).
Stony Brook University · USUniversity of Tennessee Health Science Center · USNational Institute on Aging · USUniversity of California, San Francisco · US
Funding
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MTRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000181 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 1989 to 2025
$6.2MPeripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5MEnd of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7MNitrite benefits to mediate fatigability in older HFpEF patientsR56AG051637 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORMAN, DANIEL E. · 2016 to 2016
$595kExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R56AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2010 to 2010
$300kNIA NIH HHS P30 AG024827NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028050NIA NIH HHS R56 AG023629NIA NIH HHS R56 AG051637NIA NIH HHS T32 AG000181NIDDK NIH HHS P30 DK098722NINR NIH HHS R01 NR012459
Abstract
backgroundPrevalence of heart failure (HF) increases significantly with age, coinciding with age-related changes in body composition that are common and consequential. Still, body composition is rarely factored in routine HF care. METHODS AND
resultsThe Health, Aging, and Body Composition study is a prospective cohort study of nondisabled adults. Using yearly dual-energy x-ray absorptiometry, body composition was assessed in the Health, Aging, and Body Composition study over 6 years, comparing those who developed incident HF versus those who did not. Among 2815 Health, Aging, and Body Composition participants (48.5% men; 59.6% whites; mean age, 73.6±2.9 years), 111 developed incident HF over the 6-year study period. At entry into the Health, Aging, and Body Composition study, men and women who later developed HF had higher total body mass when compared with those versus those who did not develop HF (men, 80.9±10 versus 78.6±12.9 kg,
conclusionsIncident HF in older adults was associated with disproportionate loss of lean mass, particularly among men. Prognostic implications are significant, with key sex-specific inferences on physical function, frailty, disability, and pharmacodynamics that all merit further investigation.
Indexed as
AgingBody CompositionHealth StatusAbsorptiometry, PhotonAdiposityAgedAge FactorsComorbidityFemaleHeart FailureHumansIncidenceMalePrognosisProspective StudiesRisk Factorsagingatrophybody compositionprognosissarcopenia
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