ArticleThe European respiratory journal2017
Treating breathlessness
Article in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Effects of Baduanjin Exercise on lung function and 6 min walk in COPD patients: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Trial
- Pulmonary rehabilitation in Iranian outpatients with mustard gas lung disease: a randomised controlled trial.BMJ open · 2024Trial
- Trial
- High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Therapy in Amyotrophic Lateral Sclerosis: Study Protocol for a Multicenter Randomized Controlled Clinical Trial.Journal of clinical medicine · 2025Article
- Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge.Scientific reports · 2025Article
- Incorporating uncertainty within dynamic interoceptive learning.Frontiers in psychology · 2024Article
- Changes in COPD-related anxiety symptoms during pulmonary rehabilitation: a prospective quantitative and qualitative study.Frontiers in rehabilitation sciences · 2024Article
- Efficacy and cerebral mechanisms of acupuncture for chronic obstructive pulmonary disease: study protocol for a multicenter, randomized controlled neuroimaging trial.Frontiers in neurology · 2024Article
- Pulmonary Rehabilitation with and without a Cognitive Behavioral Intervention for Breathlessness in People Living with Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial.Journal of clinical medicine · 2023Article
- Virtual reality intervention alleviates dyspnoea in patients recovering from COVID-19 pneumonia.ERJ open research · 2023Article
- The effect of d-cycloserine on brain processing of breathlessness over pulmonary rehabilitation: an experimental medicine study.ERJ open research · 2023Article
- Puzzled by dysfunctional breathing disorder(s)? Consider the Bayesian brain hypothesis!Frontiers in neuroscience · 2023Article
- Article
- Characteristics of individuals with moderate to severe asthma who better respond to aerobic training: a cluster analysis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023Article
- Investigation of altered spontaneous brain activity in patients with bronchial asthma using the percent amplitude of fluctuation method: a resting-state functional MRI study.Frontiers in human neuroscience · 2023Article
- Baseline Psychological Traits Contribute to Lake Louise Acute Mountain Sickness Score at High Altitude.High altitude medicine & biology · 2022Article
- The impact of emotional context on neural substrates of respiratory sensory gating.Frontiers in neuroscience · 2022Article
- Article
- Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Breathlessness in chronic obstructive pulmonary disease (COPD) is often discordant with airway pathophysiology ("over-perception"). Pulmonary rehabilitation profoundly affects breathlessness, without influencing lung function. Learned associations influence brain mechanisms of sensory perception. We hypothesised that improvements in breathlessness with pulmonary rehabilitation may be explained by changing neural representations of learned associations.In 31 patients with COPD, we tested how pulmonary rehabilitation altered the relationship between brain activity during a breathlessness-related word-cue task (using functional magnetic resonance imaging), and clinical and psychological measures of breathlessness.Changes in ratings of breathlessness word cues positively correlated with changes in activity in the insula and anterior cingulate cortex. Changes in ratings of breathlessness-anxiety negatively correlated with activations in attention regulation and motor networks. Baseline activity in the insula, anterior cingulate cortex and prefrontal cortex correlated with improvements in breathlessness and breathlessness-anxiety.Pulmonary rehabilitation is associated with altered neural responses related to learned breathlessness associations, which can ultimately influence breathlessness perception. These findings highlight the importance of targeting learned associations within treatments for COPD, demonstrating how neuroimaging may contribute to patient stratification and more successful personalised therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.