Evidence map›Paper›PMID 28899915›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice.

Diara A Santiago González, Veronica T Cheli, Norma N Zamora, Tenzing N Lama, Vilma Spreuer, Geoffrey G Murphy, Pablo M Paez

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. A computational roadmap to activity-dependent myelination.Frontiers in computational neuroscience · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Physiology of Oligodendroglia.Advances in neurobiology · 2025
    Review
  9. Selective blockade of CaNature communications · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Transferrin Receptor Is Necessary for Proper Oligodendrocyte Iron Homeostasis and Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  14. Transcriptional and bioinformatic analysis of GABAFrontiers in molecular neuroscience · 2023
    Article
  15. Review
  16. Neuronal deletion of CaScientific reports · 2022
    Article
  17. Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Diara A Santiago GonzálezHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
Veronica T CheliHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
Norma N ZamoraHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
Tenzing N LamaHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
Vilma SpreuerHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and.
Geoffrey G MurphyMolecular and Behavioral Neuroscience Institute, Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109.
Pablo M PaezHunter James Kelly Research Institute, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203, and ppaez@buffalo.edu.ORCID 0000-0001-9362-9454
New York University · USUniversity of Michigan · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Enabling Access to Cutting-Edge Biomedical and Behavioral ScienceR25GM095459 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2012 to 2021
$4.4M
Modulation of Oligodendrocyte Development by Voltage-Operated Calcium ChannelsR01NS078041 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Pablo Martin Paez · 2013 to 2026
$3.8M
Testing the Calcium Hypothesis of Age-related Cognitive DeclineR01AG052934 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURPHY, GEOFFREY G · 2016 to 2020
$2.1M
NCATS NIH HHS UL1 TR001412NIA NIH HHS R01 AG052934NIGMS NIH HHS R25 GM095459NINDS NIH HHS R01 NS078041
6 · The paper itself

Abstract

Exploring the molecular mechanisms that drive the maturation of oligodendrocyte progenitor cells (OPCs) during the remyelination process is essential to developing new therapeutic tools to intervene in demyelinating diseases such as multiple sclerosis. To determine whether L-type voltage-gated calcium channels (L-VGCCs) are required for OPC development during remyelination, we generated an inducible conditional knock-out mouse in which the L-VGCC isoform Cav1.2 was deleted in NG2-positive OPCs (Cav1.2

Indexed as

Gene DeletionAnimalsAntigensBrainCalcium Channels, L-TypeChondroitin Sulfate Proteoglycan 4FemaleMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyelin SheathNerve Fibers, MyelinatedOligodendrogliaProteoglycansAntigensCACNA1C protein, mouseCalcium Channels, L-TypeChondroitin Sulfate Proteoglycan 4ProteoglycansCav1.2cuprizoneoligodendrocyteremyelinationvoltage-operated Ca2+ channels

Identifiers

PMID28899915
PMCPMC5647766
OpenAlexW2754866153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.