Trial reportPhysiological reports2017
Military training elicits marked increases in plasma metabolomic signatures of energy metabolism, lipolysis, fatty acid oxidation, and ketogenesis.
Trial report in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Mapping smart technologies and nutritional strategies for monitoring cognitive resilience in military personnel under extreme operational conditions: a scoping review.Frontiers in nutrition · 2026Pooled it
- The Importance of Lipidomic Approach for Mapping and Exploring the Molecular Networks Underlying Physical Exercise: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Metabolomics of testosterone enanthate administration during severe-energy deficit.Metabolomics : Official journal of the Metabolomic Society · 2022Trial
- Effects of acute arginine supplementation on neuroendocrine, metabolic, cardiovascular, and mood outcomes in younger men: A double-blind, placebo-controlled trial.Nutrition (Burbank, Los Angeles County, Calif.) · 2022Trial
- Metabolomic profiles are reflective of hypoxia-induced insulin resistance during exercise in healthy young adult males.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Trial
- Military training elicits marked increases in plasma metabolomic signatures of energy metabolism, lipolysis, fatty acid oxidation, and ketogenesis.Physiological reports · 2017Trial
- Review
- Metabolomic responses are more sensitive in muscle than serum following 28 days of arduous exercise with erythropoietin administration.Experimental physiology · 2026Article
- Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population.Molecular nutrition & food research · 2025Article
- Cold operational readiness in the military: from science to practice.BMJ military health · 2025Review
- Comparative analysis of circulating metabolomic profiles identifies shared metabolic alterations across distinct multistressor military training exercises.Physiological genomics · 2024Article
- Effects of short-term moderate intensity exercise on the serum metabolome in older adults: a pilot randomized controlled trial.Communications medicine · 2024Article
- Performance nutrition for cold-weather military operations.International journal of circumpolar health · 2023Article
- The interactive effects of psychosocial stress and diet composition on health in primates.Neuroscience and biobehavioral reviews · 2023Review
- Sex differences in body composition and serum metabolome responses to sustained, physical training suggest enhanced fat oxidation in women compared with men.Physiological genomics · 2023Article
- Biomarkers of oxidative stress, diet and exercise distinguish soldiers selected and non-selected for special forces training.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Moderate-intensity continuous training has time-specific effects on the lipid metabolism of adolescents.Journal of translational internal medicine · 2023Article
- Associations of the Lipidome with Ageing, Cognitive Decline and Exercise Behaviours.Metabolites · 2022Review
- Initial military training modulates serum fatty acid and amino acid metabolites.Physiological reports · 2022Article
- Military training-related abdominal injuries and diseases: Common types, prevention and treatment.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Military training studies provide unique insight into metabolic responses to extreme physiologic stress induced by multiple stressor environments, and the impacts of nutrition in mediating these responses. Advances in metabolomics have provided new approaches for extending current understanding of factors modulating dynamic metabolic responses in these environments. In this study, whole-body metabolic responses to strenuous military training were explored in relation to energy balance and macronutrient intake by performing nontargeted global metabolite profiling on plasma collected from 25 male soldiers before and after completing a 4-day, 51-km cross-country ski march that produced high total daily energy expenditures (25.4 MJ/day [SD 2.3]) and severe energy deficits (13.6 MJ/day [SD 2.5]). Of 737 identified metabolites, 478 changed during the training. Increases in 88% of the free fatty acids and 91% of the acylcarnitines, and decreases in 88% of the mono- and diacylglycerols detected within lipid metabolism pathways were observed. Smaller increases in 75% of the tricarboxylic acid cycle intermediates, and 50% of the branched-chain amino acid metabolites detected were also observed. Changes in multiple metabolites related to lipid metabolism were correlated with body mass loss and energy balance, but not with energy and macronutrient intakes or energy expenditure. These findings are consistent with an increase in energy metabolism, lipolysis, fatty acid oxidation, ketogenesis, and branched-chain amino acid catabolism during strenuous military training. The magnitude of the energy deficit induced by undereating relative to high energy expenditure, rather than macronutrient intake, appeared to drive these changes, particularly within lipid metabolism pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.