Evidence map›Paper›PMID 28899909›Full record

ArticlePhysiological reports2017

Depletion of the mRNA translation initiation inhibitor, programmed cell death protein 4 (PDCD4), impairs L6 myotube formation.

Naomi Maeda, Abdikarim Abdullahi, Brendan Beatty, Zameer Dhanani, Olasunkanmi A J Adegoke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Naomi MaedaSchool of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada.
Abdikarim AbdullahiSchool of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada.
Brendan BeattySchool of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada.
Zameer DhananiSchool of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada.
Olasunkanmi A J AdegokeSchool of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada oadegoke@yorku.ca.
York University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanistic (mammalian) target of rapamycin complex 1 (mTORC1) signaling is vital for optimal muscle mass and function. Although the significance of mTORC1 in stimulating muscle growth is unequivocal, evidence in support of its role during muscle regeneration is less clear. Here, we showed that the abundance (protein and mRNA) of the mTORC1/S6K1 substrate, programmed cell death protein 4 (PDCD4), is upregulated at the onset of differentiation of L6 and C2C12 cells. The increase in PDCD4 was not associated with any changes in S6K1 activation, but the abundance of beta transducing repeat-containing protein (

Indexed as

Cell DifferentiationAnimalsApoptosisApoptosis Regulatory Proteinsbeta-Transducin Repeat-Containing ProteinsCell LineMechanistic Target of Rapamycin Complex 1MiceMuscle Fibers, SkeletalRatsRibosomal Protein S6 KinasesUp-RegulationApoptosis Regulatory Proteinsbeta-Transducin Repeat-Containing ProteinsMechanistic Target of Rapamycin Complex 1Pdcd4 protein, ratRibosomal Protein S6 KinasesRps6kb1 protein, ratApoptosismuscle regenerationmyogenesisPDCD4skeletal muscle

Identifiers

PMID28899909
PMCPMC5599859
OpenAlexW2755382968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.