ArticlePhysiological reports2017
Activation of the "Splenocardiac Axis" by electronic and tobacco cigarettes in otherwise healthy young adults.
Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Arrhythmogenic effects of acute electronic cigarette compared to tobacco cigarette smoking in people living with HIV.Physiological reports · 2024Trial
- Cardiac Autonomic Dysfunction and Increased Oxidative Stress in Conventional Cigarettes and E-Cigarettes: Heart Rate Variability as a Cardiovascular Predictor.Antioxidants (Basel, Switzerland) · 2025Review
- Review
- Vascular and Cardiovascular Outcomes of Smoking Cessation and Switching to Electronic Cigarette Use: Protocol for a Systematic Review of Prospective Studies.JMIR research protocols · 2025Article
- Ventricular Repolarization in Healthy Young Adults Who Use Combusted Cannabis: A Cross-Sectional Parallel Group Comparison Study.Journal of the American Heart Association · 2025Article
- Association of the use of e-cigarettes, combustible cigarettes or dual use with hypertension and mortality in hypertensive individuals: Insights from NHANES 2015-2018.Tobacco induced diseases · 2024Article
- Cardiotoxicity of Electronic Cigarettes and Heat-Not-Burn Tobacco Products-A Problem for the Modern Pediatric Cardiologist.Healthcare (Basel, Switzerland) · 2023Review
- Neural-hematopoietic-inflammatory axis in nonsmokers, electronic cigarette users, and tobacco smokers.Physiological reports · 2022Article
- RETRACTED: Effect Comparison of E-Cigarette and Traditional Smoking and Association with Stroke-A Cross-Sectional Study of NHANES.Neurology international · 2022Article
- Electronic Cigarette Use and the Risk of Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2022Review
- High prevalence of hypertension among smokers of conventional and e-cigarette: Using the nationally representative community dwelling survey.Frontiers in public health · 2022Article
- E-Cigarette Use: Device Market, Study Design, and Emerging Evidence of Biological Consequences.International journal of molecular sciences · 2021Review
- Electronic and Tobacco Cigarettes Alter Polyunsaturated Fatty Acids and Oxidative Biomarkers.Circulation research · 2021Article
- Electric cigarette-related lung injury and cardiovascular insult.BMJ case reports · 2021Article
- Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users.Journal of the American Heart Association · 2020Article
- Cardiovascular effects of electronic cigarettes.Nature reviews. Cardiology · 2020Article
- Cardiovascular risk of electronic cigarettes: a review of preclinical and clinical studies.Cardiovascular research · 2020Review
- Electronic Cigarettes and Cardiovascular Risk: Caution Waiting for Evidence.European cardiology · 2019Review
- Electronic cigarettes and cardiovascular health: what do we know so far?Vascular health and risk management · 2019Review
- Activation of the "Splenocardiac Axis" by electronic and tobacco cigarettes in otherwise healthy young adults.Physiological reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The "Splenocardiac Axis" describes an inflammatory signaling network underlying acute cardiac ischemia, characterized by sympathetic nerve stimulation of hematopoietic tissues, such as the bone marrow and spleen, which then release proinflammatory monocytes that populate atherosclerotic plaques, thereby promoting ischemic heart disease. Electronic (e) cigarettes, like tobacco cigarettes trigger sympathetic nerve activation, but virtually nothing is known about their influence on hematopoietic and vascular tissues and cardiovascular risks. The objective of this study was to determine if the Splenocardiac Axis is activated in young adults who habitually use either tobacco or e-cigarettes. In otherwise healthy humans who habitually use tobacco cigarettes or e-cigarettes (not both), we used
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.