ArticleJournal of the American Heart Association2017
Impact of Worsened Metabolic Syndrome on the Risk of Dementia: A Nationwide Cohort Study.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Metabolic syndrome and risk of incident all-cause dementia, Alzheimer's disease and vascular dementia: a systematic review and meta-analysis of longitudinal studies.Alzheimer's research & therapy · 2025Pooled it
- Metabolic Syndrome and Dementia Risk in Older Adults: A Narrative Review.The Kaohsiung journal of medical sciences · 2026Review
- Effects of Changes in Metabolic Syndrome Status on Cognitive Function: A 10-Year Study in a Middle-Aged Population.The Kaohsiung journal of medical sciences · 2026Article
- Article
- The Effect of Chronic Inflammation and Oxidative Stress on Alzheimer's Disease Progression: A Systematic Review.Cureus · 2025Review
- The Link between Metabolic Syndrome and the Brain.Digestion · 2025Review
- Longitudinal Association of Changes in Metabolic Syndrome with Cognitive Function: 12-Year Follow-up of the Guangzhou Biobank Cohort Study.Diabetes & metabolism journal · 2025Article
- Association between alcohol consumption and chronic kidney disease: a population-based survey.Clinical and experimental nephrology · 2024Article
- Association of Metabolic Syndrome With Neuroimaging and Cognitive Outcomes in the UK Biobank.Diabetes care · 2024Article
- Investigating the nexus of metabolic syndrome, serum uric acid, and dementia risk: a prospective cohort study.BMC medicine · 2024Article
- Association between metabolic syndrome and risk of incident dementia in UK Biobank.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study.The journal of prevention of Alzheimer's disease · 2024Article
- Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer's disease.Alzheimer's research & therapy · 2023Article
- Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome.Scientific reports · 2022Article
- Association of Metabolic Syndrome With Incident Dementia: Role of Number and Age at Measurement of Components in a 28-Year Follow-up of the Whitehall II Cohort Study.Diabetes care · 2022Article
- High sensitivity C-reactive protein and glycated hemoglobin levels as dominant predictors of all-cause dementia: a nationwide population-based cohort study.Immunity & ageing : I & A · 2022Article
- Metabolic Syndrome and Cognitive Function.Current cardiology reports · 2021Review
- Targeting Insulin Resistance to Treat Cognitive Dysfunction.Molecular neurobiology · 2021Review
- Gender- and age-related differences of statin use on incident dementia in patients with rheumatoid arthritis: a Nationwide population-based cohort study.Lipids in health and disease · 2021Article
- Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study.Endocrinology and metabolism (Seoul, Korea) · 2021 · on this mapArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship of alteration of metabolic syndrome (MetS) with dementia remains unclear. The purpose of study was to evaluate the association between dynamic change in MetS status around a 5-year period and dementia. METHODS AND
resultsThe cohort study was conducted from the Taiwanese Survey on Prevalence of Hypertension, Hyperglycemia, and Hyperlipidemia in 2002, with follow-up in 2007. The sample was subsequently linked to the National Health Insurance Research Database. Participants were divided into 3 groups: persistent MetS (MetS both in 2002 and 2007); nonpersistent MetS (MetS either in 2002 or 2007); and non-MetS (MetS neither in 2002 nor 2007). Furthermore, the individuals with nonpersistent MetS were categorized as improved MetS (MetS in 2002 but not in 2007) and worsened MetS (MetS not in 2002 but in 2007). Each participant was tracked until the end of 2011 to identify the development of dementia. In total, 3458 participants aged 40 to 80 years were included. Up to 10 years and 31 741 person-years of follow-up, 76 patients developed dementia. Only a relationship was found between the nonpersistent MetS and dementia (adjusted hazard ratio=1.93; 95% confidence interval =1.17-3.19;
conclusionsPatients with worsened MetS had an increased dementia risk during the 10-year follow-up period in a population-based sample.
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