Evidence map›Paper›PMID 28899742›Full record

ArticleNeuroImage2017

ICN_Atlas: Automated description and quantification of functional MRI activation patterns in the framework of intrinsic connectivity networks.

Lajos R Kozák, Louis André van Graan, Umair J Chaudhary, Ádám György Szabó, Louis Lemieux

Open access · hybridAbstract read
In one paragraph

Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. aXonica: A support package for MRI based Neuroimaging.Biotechnology notes (Amsterdam, Netherlands) · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A Precuneal Causal Loop Mediates External and Internal Information Integration in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lajos R KozákMR Research Center, Semmelweis University, 1085, Budapest, Hungary. Electronic address: lrkozak@gmail.com.
Louis André van GraanDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, WC1N 3BG, London, UK; Epilepsy Society, SL9 0RJ Chalfont St. Peter, Buckinghamshire, UK. Electronic address: louis.graan.12@ucl.ac.uk.
Umair J ChaudharyDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, WC1N 3BG, London, UK; Epilepsy Society, SL9 0RJ Chalfont St. Peter, Buckinghamshire, UK. Electronic address: umair.chaudhary@alumni.ucl.ac.uk.
Ádám György SzabóMR Research Center, Semmelweis University, 1085, Budapest, Hungary. Electronic address: szabadam@gmail.com.
Louis LemieuxDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, WC1N 3BG, London, UK; Epilepsy Society, SL9 0RJ Chalfont St. Peter, Buckinghamshire, UK. Electronic address: louis.lemieux@ucl.ac.uk.
Epilepsy Society · GBSemmelweis University · HU

Funding

Medical Research Council G0200216Medical Research Council G0301067
6 · The paper itself

Abstract

Generally, the interpretation of functional MRI (fMRI) activation maps continues to rely on assessing their relationship to anatomical structures, mostly in a qualitative and often subjective way. Recently, the existence of persistent and stable brain networks of functional nature has been revealed; in particular these so-called intrinsic connectivity networks (ICNs) appear to link patterns of resting state and task-related state connectivity. These networks provide an opportunity of functionally-derived description and interpretation of fMRI maps, that may be especially important in cases where the maps are predominantly task-unrelated, such as studies of spontaneous brain activity e.g. in the case of seizure-related fMRI maps in epilepsy patients or sleep states. Here we present a new toolbox (ICN_Atlas) aimed at facilitating the interpretation of fMRI data in the context of ICN. More specifically, the new methodology was designed to describe fMRI maps in function-oriented, objective and quantitative way using a set of 15 metrics conceived to quantify the degree of 'engagement' of ICNs for any given fMRI-derived statistical map of interest. We demonstrate that the proposed framework provides a highly reliable quantification of fMRI activation maps using a publicly available longitudinal (test-retest) resting-state fMRI dataset. The utility of the ICN_Atlas is also illustrated on a parametric task-modulation fMRI dataset, and on a dataset of a patient who had repeated seizures during resting-state fMRI, confirmed on simultaneously recorded EEG. The proposed ICN_Atlas toolbox is freely available for download at http://icnatlas.com and at http://www.nitrc.org for researchers to use in their fMRI investigations.

Indexed as

Atlases as TopicBrainBrain MappingHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingNerve NetNeural PathwaysBrain atlasData analysisFunctional characterizationFunctional magnetic resonance imagingIntrinsic connectivity networksResting-state networks

Identifiers

PMID28899742
PMCPMC5725313
OpenAlexW2751977366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.