Evidence map›Paper›PMID 28899614›Full record

ArticlePsychiatry research2017

Measuring pathology using the PANSS across diagnoses: Inconsistency of the positive symptom domain across schizophrenia, schizoaffective, and bipolar disorder.

Ariana E Anderson, Maxwell Mansolf, Steven P Reise, Adam Savitz, Giacomo Salvadore, Qingqin Li, Robert M Bilder

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  8. Circulating endothelial progenitor cell dysfunction in patients with bipolar disorder.European archives of psychiatry and clinical neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ariana E AndersonUniversity of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA; University of California, Los Angeles, Department of Statistics, Los Angeles, CA, USA. Electronic address: arianaanderson@mednet.ucla.edu.
Maxwell MansolfUniversity of California, Los Angeles, Department of Psychology, Los Angeles, CA, USA.
Steven P ReiseUniversity of California, Los Angeles, Department of Psychology, Los Angeles, CA, USA.
Adam SavitzJanssen Scientific Affairs, Titusville, NJ, USA.
Giacomo SalvadoreJanssen Scientific Affairs, Titusville, NJ, USA.
Qingqin LiJanssen Scientific Affairs, Titusville, NJ, USA.
Robert M BilderUniversity of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA; University of California, Los Angeles, Department of Psychology, Los Angeles, CA, USA.

Funding

Human Translational Applications Core (HTA - Core) (7 of 8)PL1MH083271 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2007 to 2011
$5.8M
Multi-Level Assays of Working Memory and PsychopathologyR01MH101478 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2014 to 2018
$3.0M
Consortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)UL1DE019580 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2008 to 2011
$1.9M
Hemodynamic Biomarkers of Healthy and Diseased AgingK25AG051782 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANDERSON, ARIANA · 2016 to 2020
$667k
Modeling RDoc Dimensions Across Levels of AnalysisR03MH106922 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANDERSON, ARIANA · 2016 to 2017
$154k
NIA NIH HHS K25 AG051782NIDCR NIH HHS UL1 DE019580NIMH NIH HHS PL1 MH083271NIMH NIH HHS R01 MH101478NIMH NIH HHS R03 MH106922
6 · The paper itself

Abstract

Although the Positive and Negative Syndrome Scale (PANSS) was developed for use in schizophrenia (SZ), antipsychotic drug trials use the PANSS to measure symptom change also for bipolar (BP) and schizoaffective (SA) disorder, extending beyond its original indications. If the dimensions measured by the PANSS are different across diagnoses, then the same score change for the same drug condition may have different meanings depending on which group is being studied. Here, we evaluated whether the factor structure in the PANSS was consistent across schizophrenia (n = 3647), bipolar disorder (n = 858), and schizoaffective disorder (n = 592). Along with congruency coefficients, Hancock's H, and Jaccard indices, we used target rotations and statistical tests of invariance based on confirmatory factor models. We found the five symptom dimensions measured by the 30-item PANSS did not generalize well to schizoaffective and bipolar disorders. A model based on an 18-item version of the PANSS generalized better across SZ and BP groups, but significant problems remained in generalizing some of the factors to the SA sample. Schizophrenia and bipolar disorder showed greater similarity in factor structure than did schizophrenia and schizoaffective disorder. The Anxiety/Depression factor was the most consistent across disorders, while the Positive factor was the least consistent.

Indexed as

Schizophrenic PsychologyAdultAgedAnxietyBipolar DisorderDepressionFemaleHumansMalePsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaAntipsychoticAnxietyClinical trialsDrug trialsFactor analysesFactor structureNegative symptoms

Identifiers

PMID28899614
PMCPMC5681392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.