Evidence map›Paper›PMID 28899445›Full record

ArticleInfection control and hospital epidemiology2017

Microbial Disruption Indices to Detect Colonization With Multidrug-Resistant Organisms.

Rafael Araos, Veronica Montgomery, Juan A Ugalde, Graham M Snyder, Erika M C D'Agata

Abstract read
In one paragraph

Article in Infection control and hospital epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. High Burden of Intestinal Colonization With Antimicrobial-Resistant Bacteria in Chile: An Antibiotic Resistance in Communities and Hospitals (ARCH) Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rafael Araos1Genomics and Resistant Microbes (GeRM) Group, Facultad de Medicina Clínica AlemanaUniversidad del Desarrollo,Santiago,Chile.
Veronica Montgomery2Department of Biomedical Engineering,Georgia Institute of Technology,Atlanta,Georgia.
Juan A Ugalde3Centro de Genética y Genómica, Facultad de Medicina Clínica AlemanaUniversidad del Desarrollo,Santiago,Chile.
Graham M Snyder4Department of Medicine,Division of Infectious Diseases,Beth Israel Deaconess Medical Center,Boston,MA.
Erika M C D'Agata5Rhode Island Hospital,Brown University,Providence,Rhode Island.

Funding

Midcareer Investigator Award in Patient-Oriented ResearchK24AI119158 · NIAID · RHODE ISLAND HOSPITAL · PI D'AGATA, ERIKA M · 2016 to 2020
$885k
NIAID NIH HHS K24 AI119158
6 · The paper itself

Abstract

OBJECTIVE To characterize the microbial disruption indices of hospitalized patients to predict colonization with multidrug-resistant organisms (MDROs). DESIGN A cross-sectional survey of the fecal microbiome was conducted in a tertiary referral, acute-care hospital in Boston, Massachusetts. PARTICIPANTS The study population consisted of adult patients hospitalized in general medical/surgical wards. METHODS Rectal swabs were obtained from patients within 48 hours of hospital admission and screened for MDRO colonization using conventional culture techniques. The V4 region of the 16S rRNA gene was sequenced to assess the fecal microbiome. Microbial diversity and composition, as well as the functional potential of the microbial communities present in fecal samples, were compared between patients with and without MDRO colonization. RESULTS A total of 44 patients were included in the study, of whom 11 (25%) were colonized with at least 1 MDRO. Reduced microbial diversity and high abundance of metabolic pathways associated with multidrug-resistance mechanisms characterized the fecal microbiome of patients colonized with MDRO at hospital admission. CONCLUSIONS Our data suggest that microbial disruption indices may be key to predicting MDRO colonization and could provide novel infection control approaches. Infect Control Hosp Epidemiol 2017;38:1312-1318.

Indexed as

AgedCross InfectionCross-Sectional StudiesDrug Resistance, Multiple, BacterialFecesFemaleHumansMaleMicrobiotaMiddle AgedRNA, Ribosomal, 16STertiary Care CentersRNA, Ribosomal, 16S

Identifiers

PMID28899445
PMCPMC6262892

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.