ArticleArthritis research & therapy2017
Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis.
Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 88 citations in OpenAlex.
- The Role of Ultrasound Versus Radiography in Knee Osteoarthritis: A Bilateral Comparative Study.Life (Basel, Switzerland) · 2026Article
- Medial Meniscus Extrusion During Weight-Bearing in Early-Stage Knee Osteoarthritis.Annals of biomedical engineering · 2026Article
- Relationship between medial meniscus extrusion and osteophyte formation in early-stage knee osteoarthritis: an ultrasound-based multicenter cross-sectional study.Journal of medical ultrasonics (2001) · 2026Article
- Frequency and mutual associations of knee osteoarthritis features on ultrasound imaging in recent-onset symptomatic knee osteoarthritis patients: A cross-sectional analysis in a convenience sample of Dutch patients.Osteoarthritis and cartilage open · 2026Article
- Micro-computed tomographical and histopathological analyses of medial tibial plateaus from patients with subchondral insufficiency fracture or osteoarthritis of the knee.Arthritis research & therapy · 2026Article
- Article
- Increased medial meniscus extrusion on ultrasonography in highly competitive rugby players: A cross-sectional study.PloS one · 2026Article
- Medial plica is associated with progression of medial meniscus extrusion in middle-aged persons with Kellgren-Lawrence grade 0: data from the osteoarthritis initiative.Journal of orthopaedic surgery and research · 2025Article
- Bone marrow lesion coexisted with subchondral bone attrition and/or subchondral bone cyst is associated with knee pain in knee osteoarthritis regardless of cartilage lesion: the Bunkyo health study.Arthritis research & therapy · 2025Article
- Progression of medial meniscal extrusion following anterior cruciate ligament reconstruction correlates with graft diameter: a retrospective longitudinal study.BMC musculoskeletal disorders · 2025Article
- Changes in the position of the medial meniscus owing to degenerative meniscus tears.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2025Article
- The changes in 3D bone morphology mediate the association between meniscal extrusion and radiographic progression of osteoarthritis: data from the Osteoarthritis Initiative.Quantitative imaging in medicine and surgery · 2025Article
- Longitudinal Changes in Medial Meniscal Extrusion After ACL Injury and Reconstruction and Its Relationship With Cartilage Degeneration Assessed Using MRI-Based T1ρ and T2 Analysis.The American journal of sports medicine · 2025Article
- Meniscal extrusion: Proposal for a novel qualitative classification.Journal of experimental orthopaedics · 2025Review
- Relationship Between the Sagittal and Coronary Alignment of the Tibiofemoral Joint and the Medial Meniscus Extrusion in Knee Osteoarthritis.Healthcare (Basel, Switzerland) · 2024Article
- Ultrasounds outperform magnetic resonance imaging in quantifying meniscal extrusion in patients with knee osteoarthritis.Journal of experimental orthopaedics · 2024Article
- Multiparametric approach with synthetic MR imaging for diagnosing salivary gland lesions.Japanese journal of radiology · 2024Article
- The Relationship Between Medial Meniscal Extrusion and Outcome Measures for Knee Osteoarthritis: A Systematic Review.Orthopaedic journal of sports medicine · 2024Review
- Effect of inside-out meniscal repair on meniscal dimension in meniscal tear patients.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2024Article
- Evaluation of the relationship between Knee Osteoarthritis and Meniscus Pathologies.Malawi medical journal : the journal of Medical Association of Malawi · 2024Article
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedial meniscal extrusion (MME) is associated with progression of medial knee osteoarthritis (OA), but no or little information is available for relationships between MME and osteophytes, which are found in cartilage and bone parts. Because of the limitation in detectability of the cartilage part of osteophytes by radiography or conventional magnetic resonance imaging (MRI), the rate of development and size of osteophytes appear to have been underestimated. Because T2 mapping MRI may enable us to evaluate the cartilage part of osteophytes, we aimed to examine the association between MME and OA-related changes, including osteophytes, by using conventional and T2 mapping MRI.
methodsPatients with early-stage knee OA (n = 50) were examined. MRI-detected OA-related changes, in addition to MME, were evaluated according to the Whole-Organ Magnetic Resonance Imaging Score. T2 values of the medial meniscus and osteophytes were measured on T2 mapping images. Osteophytes surgically removed from patients with end-stage knee OA were histologically analyzed and compared with findings derived by radiography and MRI.
resultsMedial side osteophytes were detected by T2 mapping MRI in 98% of patients with early-stage knee OA, although the detection rate was 48% by conventional MRI and 40% by radiography. Among the OA-related changes, medial tibial osteophyte distance was most closely associated with MME, as determined by multiple logistic regression analysis, in the patients with early-stage knee OA (β = 0.711, p < 0.001). T2 values of the medial meniscus were directly correlated with MME in patients with early-stage knee OA, who showed ≥ 3 mm of MME (r = 0.58, p = 0.003). The accuracy of osteophyte evaluation by T2 mapping MRI was confirmed by histological analysis of the osteophytes removed from patients with end-stage knee OA.
conclusionsOur study demonstrates that medial tibial osteophyte evaluated by T2 mapping MRI is frequently observed in the patients with early-stage knee OA, showing close association with MME, and that MME is positively correlated with the meniscal degeneration.
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