Evidence map›Paper›PMID 28899391›Full record

ArticleMicrobial cell factories2017

Mixomics analysis of Bacillus subtilis: effect of oxygen availability on riboflavin production.

Junlang Hu, Pan Lei, Ali Mohsin, Xiaoyun Liu, Mingzhi Huang, Liang Li, Jianhua Hu, Haifeng Hang, Yingping Zhuang, Meijin Guo

Open access · goldAbstract read
In one paragraph

Article in Microbial cell factories, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
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  7. Metabolic Profile of the Genome-ReducedACS synthetic biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Junlang HuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China.
Pan LeiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China.
Ali MohsinState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China.
Xiaoyun LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China.
Mingzhi HuangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China. huangmz@ecust.edu.cn.
Liang LiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China.
Jianhua HuShanghai Acebright Pharmaceuticals Group Co., Ltd, Shanghai, 201203, People's Republic of China.
Haifeng HangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China.
Yingping ZhuangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China.
Meijin GuoState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. box 329#, Shanghai, 200237, People's Republic of China. guo_mj@ecust.edu.cn.
East China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRiboflavin, an intermediate of primary metabolism, is one kind of important food additive with high economic value. The microbial cell factory Bacillus subtilis has already been proven to possess significant importance for the food industry and have become one of the most widely used riboflavin-producing strains. In the practical fermentation processes, a sharp decrease in riboflavin production is encountered along with a decrease in the dissolved oxygen (DO) tension. Influence of this oxygen availability on riboflavin biosynthesis through carbon central metabolic pathways in B. subtilis is unknown so far. Therefore the unveiled effective metabolic pathways were still an unaccomplished task till present research work.

resultsIn this paper, the microscopic regulation mechanisms of B. subtilis grown under different dissolved oxygen tensions were studied by integrating

conclusionsThis study shows that integration of transcriptomics,

Indexed as

Acetolactate SynthaseBacillus subtilisBacterial ProteinsFermentationGene Expression ProfilingGene Expression Regulation, BacterialGlycolysisMetabolic Flux AnalysisMetabolic Networks and PathwaysMetabolomicsOxygenPentose Phosphate PathwayRiboflavinAcetolactate SynthaseBacterial ProteinsOxygenRiboflavin13C metabolic flux analysisBacillus subtilisMetabolomicsOxygen availabilityRiboflavinTranscriptomics

Identifiers

PMID28899391
PMCPMC5596917
OpenAlexW2755079131

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.