ArticleBiofouling2017
RNA-Seq reveals a central role for lectin, C1q and von Willebrand factor A domains in the defensive glue of a terrestrial slug.
Article in Biofouling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- De novo genome assembly and transcriptome sequencing in foot and mantle tissues of Megaustenia siamensis reveals components of adhesive substances.Scientific reports · 2024Article
- The venom and telopodal defence systems of the centipede Lithobius forficatus are functionally convergent serial homologues.BMC biology · 2024Article
- Metal-binding proteins and cross-linking in the defensive glue of the slugJournal of the Royal Society, Interface · 2022Article
- Article
- The protein and volatile components of trail mucus in the Common Garden Snail, Cornu aspersum.PloS one · 2021Article
- Extracellular Vesicles and Post-Translational Protein Deimination Signatures in Mollusca-The Blue Mussel (Biology · 2020Article
- Molecular insights into the powerful mucus-based adhesion of limpets (Open biology · 2020Article
- Integrative Transcriptome and Proteome Analysis of the Tube Foot and Adhesive Secretions of the Sea UrchinInternational journal of molecular sciences · 2020Article
- Elasticity and energy dissipation in the double network hydrogel adhesive of the slug Arion subfuscus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Transcriptional characterisation of the Exaiptasia pallida pedal disc.BMC genomics · 2019Article
- Fingerprinting of Proteins that Mediate Quagga Mussel Adhesion using a De Novo Assembled Foot Transcriptome.Scientific reports · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The tough, hydrogel glue produced by the slug Arion subfuscus achieves impressive performance through metal-based, protein cross-links. The primary sequence of these proteins was determined through transcriptome sequencing and proteome analysis by tandem mass spectrometry. The main proteins that correlate with adhesive function are a group of 11 small, highly abundant lectin-like proteins. These proteins matched the ligand-binding C-lectin, C1q or H-lectin domains. The variety of different lectin-like proteins and their potential for oligomerization suggests that they function as versatile and potent cross-linkers. In addition, the glue contains five matrilin-like proteins that are rich in von Willebrand factor A (VWA) and EGF domains. Both C-lectins and VWA domains are known to bind to ligands using divalent cations. These findings are consistent with the double network mechanism proposed for slug glue, with divalent ions serving as sacrificial bonds to dissipate energy.
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Registered trials
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