ArticleThe Korean journal of internal medicine2018
Comparison of liquid-based cytology (CellPrepPlus) and conventional smears in pancreaticobiliary disease.
Article in The Korean journal of internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Diagnostic Efficacy of Histology Combined with Single Cytology for Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Solid Pancreatic Lesions: A Retrospective Single-Center Study.Digestive diseases and sciences · 2026Article
- EUS-FNA with ROSE for pancreatic solid lesions: a single-center experience.BMC gastroenterology · 2025Article
- Combined Liquid-Based Cytology and Conventional Smear Provides Better Sensitivity and Adequacy Rates After Endoscopic Ultrasound-Guided Tissue Acquisition of Abdominal Masses: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Role of Liquid-Based Cytology in the Endoscopic Diagnosis of Pancreatic Ductal Adenocarcinoma.Journal of clinical medicine · 2024Review
- Diagnostic Efficacy of Cell Block and Liquid-Based Cytology for Endoscopic Ultrasound-Guided Fine Needle Aspiration in Pancreatic Tumors.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Tissue processing of endoscopic ultrasound-guided fine-needle aspiration specimens from solid pancreatic lesions.Journal of medical ultrasonics (2001) · 2024Review
- Evaluation of the diagnostic efficacy of liquid-based cytology obtained via percutaneous ultrasound-guided fine-needle aspiration for pancreatic masses: a large tertiary center's 8-year experience.Journal of cancer research and clinical oncology · 2023Article
- A retrospective analysis of serous effusions based on the newly proposed international system for reporting serous fluid cytopathology: a report of 3633 cases in an oncological center.Diagnostic pathology · 2022Article
- The usefulness of liquid-based cytology for endoscopic ultrasound-guided tissue acquisition of solid pancreatic masses.Frontiers in medicine · 2022Review
- Cytohistological Correlation in Pleural Effusions Based on the International System for Reporting Serous Fluid Cytopathology.Diagnostics (Basel, Switzerland) · 2021Article
- Comparison of smear cytology with liquid-based cytology in pancreatic lesions: A systematic review and meta-analysis.World journal of clinical cases · 2021Article
- Comparison of EUS-guided conventional smear and liquid-based cytology in pancreatic lesions: A systematic review and meta-analysis.Endoscopy international open · 2020Article
- The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm.BMC gastroenterology · 2020Article
- Diagnostic value of liquid-based cytology and smear cytology in pancreatic endoscopic ultrasound-guided fine needle aspiration: A meta-analysis.World journal of clinical cases · 2020Article
- Comparison between Conventional Smear and Liquid-Based Preparation in Endoscopic Ultrasonography-Fine Needle Aspiration Cytology of Pancreatic Lesions.Diagnostics (Basel, Switzerland) · 2020Article
- Diagnostic yield and agreement on fine-needle specimens from solid pancreatic lesions : comparing the smear technique to liquid-based cytology.Endoscopy international open · 2020Article
- A comparative study of two liquid-based preparation methods: membrane-based and sedimentation in fine needle aspiration cytology diagnosis in thyroid nodules.World journal of surgical oncology · 2020Article
- UEG Week 2019 Oral Presentations.United European gastroenterology journal · 2019Article
- Diagnostic efficacy of smear plus liquid-based cytology for EUS-FNA of solid pancreatic lesions: A propensity-matched study.Medicine · 2019Article
- Optimal number of needle passes during EUS-guided fine-needle biopsy of solid pancreatic lesions with 22G ProCore needles and different suction techniques: A randomized controlled trial.Endoscopic ultrasoundArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsEndoscopic ultrasound-guided fine needle aspiration (EUSFNA) and brushing cytology are used worldwide to diagnose pancreatic and biliary malignant tumors. Liquid-based cytology (LBC) has been developed and it is currently used to overcome the limitations of conventional smears (CS). In this study, the authors aimed to compare the diagnostic value of the CellPrepPlus (CP; Biodyne) LBC method with CS in samples obtained using EUS-FNA and brushing cytology.
methodsThis study prospectively enrolled 75 patients with pancreatic or biliary lesions from June 2012 to October 2013. For cytological analyses, including inadequate specimens, benign and atypical were further classified into benign, and suspicious and malignant were subcategorized as malignant. Sensitivity, specificity, accuracy, and positive predictive values (PPV) and negative predictive values (NPV) were evaluated.
resultsIn the EUS-FNA based cytological analysis of pancreatic specimens, CP had a sensitivity of 60.7%; specificity, 100%; accuracy, 77.1%; PPV, 100%; and NPV, 64.5%. CS had a sensitivity of 85.7%; specificity, 100%; accuracy, 91.7%; PPV, 100%; and NPV, 83.3%. In the brushing cytology based analysis of biliary specimens, CP had sensitivity of 53.1%; specificity, 100%; accuracy, 54.5%; PPV, 100%; and NPV, 6.3%. CS had a sensitivity of 78.1%; specificity, 100%; accuracy, 78.8%; PPV, 100%; and NPV, 12.5%.
conclusionOur study found that CP had a lower sensitivity because of low cellularity compared with CS. Therefore, CP (LBC) has a lower diagnostic accuracy for pancreatic EUS-FNA based and biliary brush cytology based analyses compared with CS.
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