Evidence map›Paper›PMID 28899031›Full record

ReviewFEMS yeast research2017

Saccharomyces cerevisiae strains for second-generation ethanol production: from academic exploration to industrial implementation.

Mickel L A Jansen, Jasmine M Bracher, Ioannis Papapetridis, Maarten D Verhoeven, Hans de Bruijn, Paul P de Waal, Antonius J A van Maris, Paul Klaassen, Jack T Pronk

Abstract readReview
In one paragraph

Review in FEMS yeast research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Mitochondrial localization of key NADApplied and environmental microbiology · 2026
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  15. Applied and environmental microbiology · 2024
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mickel L A JansenDSM Biotechnology Centre, Alexander Fleminglaan 1, 2613 AX Delft, The Netherlands.
Jasmine M BracherDepartment of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Ioannis PapapetridisDepartment of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Maarten D VerhoevenDepartment of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Hans de BruijnDSM Biotechnology Centre, Alexander Fleminglaan 1, 2613 AX Delft, The Netherlands.
Paul P de WaalDSM Biotechnology Centre, Alexander Fleminglaan 1, 2613 AX Delft, The Netherlands.
Antonius J A van MarisDepartment of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Paul KlaassenDSM Biotechnology Centre, Alexander Fleminglaan 1, 2613 AX Delft, The Netherlands.
Jack T PronkDepartment of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent start-up of several full-scale 'second generation' ethanol plants marks a major milestone in the development of Saccharomyces cerevisiae strains for fermentation of lignocellulosic hydrolysates of agricultural residues and energy crops. After a discussion of the challenges that these novel industrial contexts impose on yeast strains, this minireview describes key metabolic engineering strategies that have been developed to address these challenges. Additionally, it outlines how proof-of-concept studies, often developed in academic settings, can be used for the development of robust strain platforms that meet the requirements for industrial application. Fermentation performance of current engineered industrial S. cerevisiae strains is no longer a bottleneck in efforts to achieve the projected outputs of the first large-scale second-generation ethanol plants. Academic and industrial yeast research will continue to strengthen the economic value position of second-generation ethanol production by further improving fermentation kinetics, product yield and cellular robustness under process conditions.

Indexed as

EthanolFermentationIndustrial MicrobiologyLigninMetabolic EngineeringMetabolic Networks and PathwaysSaccharomyces cerevisiaeEthanolLigninlignocellulosebiofuelsbiomass hydrolysatesindustrial fermentationmetabolic engineeringpentose fermentationstrain improvementyeast biotechnology

Identifiers

PMID28899031
PMCPMC5812533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.