ReviewEndocrine reviews2017
Obesity Pathogenesis: An Endocrine Society Scientific Statement.
Review in Endocrine reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 346 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
346 citing papers in PubMed, 3 syntheses or guidelines pooled it, 688 citations in OpenAlex.
- Hyperphagia in rare melanocortin-4 receptor pathway diseases: therapeutic options and assessing treatment response.Reviews in endocrine & metabolic disorders · 2025Pooled it
- Uncovering the Causal Link Between Obesity-Associated Genes and Multiple Sclerosis: A Systematic Literature Review.Brain and behavior · 2025Pooled it
- Impact of physical activity on caloric and macronutrient intake in children and adolescents: a systematic review and meta-analysis of randomized controlled trials.The international journal of behavioral nutrition and physical activity · 2024Pooled it
- Trial
- A randomized controlled trial of an acceptance and commitment therapy-informed diabetes prevention program reduces body shame and distress.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Trial
- Associations between children's dietary patterns, excessive weight gain, and obesity risk: cohort study nested to a randomized field trial.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025Trial
- Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial.Nutrition journal · 2024Trial
- Altered serum amylin and preptin levels in women with polycystic ovary syndrome: a comparative analysis based on obesity status.Journal of endocrinological investigation · 2026Article
- Family Dynamics and Longitudinal Trends in Pediatric Obesity: A Real-World Observational Study in a Public Outpatient Clinic.Obesity science & practice · 2026Article
- Preoperative Prediction of Total Small Bowel Length Using Anthropometric Measurements: Development and Internal Validation of a Model in 327 Adult Autopsies.Diagnostics (Basel, Switzerland) · 2026Article
- Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader-Willi syndrome.The Journal of physiology · 2026Article
- Prevalence of fibromyalgia in Egyptian patients with systemic lupus erythematosus and its impact on health-related quality of life.Advances in rheumatology (London, England) · 2026Article
- Does the Carbohydrate-Insulin Model Explain Obesity? Evidence from Mechanistic and Clinical Studies: A Critical Review.Current obesity reports · 2026Review
- Weight regain after obesity treatment: mechanisms, predictors, and real-world evidence from the IGOBE program.Reviews in endocrine & metabolic disorders · 2026Review
- Neuropsychological and metabolic interconnectivity in obesity, anorexia and bulimia nervosa - an integrative literature review.Metabolic brain disease · 2026Review
- Understanding eating behaviors in obesity: a DEBQ-based analysis of clinical and demographic factors.Journal of eating disorders · 2026Article
- Review
- Restoring Satiety After GLP-1/GIP Pharmacotherapy: Metabolic Stability, Diet Quality, and the Gut Microbiota.International journal of molecular sciences · 2026Review
- Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Literature Review on Pathophysiology and Treatment.Diabetes, obesity & metabolism · 2026Review
- Mapping quantitative trait loci underlying body weight changes that act at different times during high-fat diet challenge in collaborative cross mice.Animal models and experimental medicine · 2026Article
286 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Obesity is among the most common and costly chronic disorders worldwide. Estimates suggest that in the United States obesity affects one-third of adults, accounts for up to one-third of total mortality, is concentrated among lower income groups, and increasingly affects children as well as adults. A lack of effective options for long-term weight reduction magnifies the enormity of this problem; individuals who successfully complete behavioral and dietary weight-loss programs eventually regain most of the lost weight. We included evidence from basic science, clinical, and epidemiological literature to assess current knowledge regarding mechanisms underlying excess body-fat accumulation, the biological defense of excess fat mass, and the tendency for lost weight to be regained. A major area of emphasis is the science of energy homeostasis, the biological process that maintains weight stability by actively matching energy intake to energy expenditure over time. Growing evidence suggests that obesity is a disorder of the energy homeostasis system, rather than simply arising from the passive accumulation of excess weight. We need to elucidate the mechanisms underlying this "upward setting" or "resetting" of the defended level of body-fat mass, whether inherited or acquired. The ongoing study of how genetic, developmental, and environmental forces affect the energy homeostasis system will help us better understand these mechanisms and are therefore a major focus of this statement. The scientific goal is to elucidate obesity pathogenesis so as to better inform treatment, public policy, advocacy, and awareness of obesity in ways that ultimately diminish its public health and economic consequences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.