Evidence map›Paper›PMID 28898959›Full record

Trial reportThe international journal of neuropsychopharmacology2017

Cognitive Training Using a Novel Memory Game on an iPad in Patients with Amnestic Mild Cognitive Impairment (aMCI).

George Savulich, Thomas Piercy, Chris Fox, John Suckling, James B Rowe, John T O'Brien, Barbara J Sahakian

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The international journal of neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 17 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 17 syntheses or guidelines pooled it, 175 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

George SavulichDepartment of Psychiatry (Dr Savulich, Mr Piercy, and Profs Suckling, O'Brien, and Sahakian), and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute (Dr Savulich, Mr Piercy, and Profs Suckling, Rowe, and Sahakian) University of Cambridge, Cambridge, United Kingdom; Department of Psychological Sciences, University of East Anglia, Norwich, United Kingdom (Prof Fox); Department of Clinical Neurosciences and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom (Prof Rowe).
Thomas PiercyDepartment of Psychiatry (Dr Savulich, Mr Piercy, and Profs Suckling, O'Brien, and Sahakian), and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute (Dr Savulich, Mr Piercy, and Profs Suckling, Rowe, and Sahakian) University of Cambridge, Cambridge, United Kingdom; Department of Psychological Sciences, University of East Anglia, Norwich, United Kingdom (Prof Fox); Department of Clinical Neurosciences and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom (Prof Rowe).
Chris FoxDepartment of Psychiatry (Dr Savulich, Mr Piercy, and Profs Suckling, O'Brien, and Sahakian), and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute (Dr Savulich, Mr Piercy, and Profs Suckling, Rowe, and Sahakian) University of Cambridge, Cambridge, United Kingdom; Department of Psychological Sciences, University of East Anglia, Norwich, United Kingdom (Prof Fox); Department of Clinical Neurosciences and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom (Prof Rowe).
John SucklingDepartment of Psychiatry (Dr Savulich, Mr Piercy, and Profs Suckling, O'Brien, and Sahakian), and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute (Dr Savulich, Mr Piercy, and Profs Suckling, Rowe, and Sahakian) University of Cambridge, Cambridge, United Kingdom; Department of Psychological Sciences, University of East Anglia, Norwich, United Kingdom (Prof Fox); Department of Clinical Neurosciences and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom (Prof Rowe).
James B RoweDepartment of Psychiatry (Dr Savulich, Mr Piercy, and Profs Suckling, O'Brien, and Sahakian), and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute (Dr Savulich, Mr Piercy, and Profs Suckling, Rowe, and Sahakian) University of Cambridge, Cambridge, United Kingdom; Department of Psychological Sciences, University of East Anglia, Norwich, United Kingdom (Prof Fox); Department of Clinical Neurosciences and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom (Prof Rowe).
John T O'BrienDepartment of Psychiatry (Dr Savulich, Mr Piercy, and Profs Suckling, O'Brien, and Sahakian), and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute (Dr Savulich, Mr Piercy, and Profs Suckling, Rowe, and Sahakian) University of Cambridge, Cambridge, United Kingdom; Department of Psychological Sciences, University of East Anglia, Norwich, United Kingdom (Prof Fox); Department of Clinical Neurosciences and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom (Prof Rowe).
Barbara J SahakianDepartment of Psychiatry (Dr Savulich, Mr Piercy, and Profs Suckling, O'Brien, and Sahakian), and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute (Dr Savulich, Mr Piercy, and Profs Suckling, Rowe, and Sahakian) University of Cambridge, Cambridge, United Kingdom; Department of Psychological Sciences, University of East Anglia, Norwich, United Kingdom (Prof Fox); Department of Clinical Neurosciences and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom (Prof Rowe).
Wellcome Trust · GBUniversity of Cambridge · GBUniversity of East Anglia · GB

Funding

Medical Research Council MC_U105597119Medical Research Council MC_UU_00005/12Wellcome Trust 103838
6 · The paper itself

Abstract

Background: Cognitive training is effective in patients with mild cognitive impairment but does not typically address the motivational deficits associated with older populations with memory difficulties. Methods: We conducted a randomized controlled trial of cognitive training using a novel memory game on an iPad in 42 patients with a diagnosis of amnestic mild cognitive impairment assigned to either the cognitive training (n=21; 8 hours of gameplay over 4 weeks) or control (n=21; clinic visits as usual) groups. Results: Significant time-by-pattern-by-group interactions were found for cognitive performance in terms of the number of errors made and trials needed on the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning task (P=.044; P=.027). Significant time-by-group interactions were also found for the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning first trial memory score (P=.002), Mini-Mental State Examination (P=.036), the Brief Visuospatial Memory Test (P=.032), and the Apathy Evaluation Scale (P=.026). Within-group comparisons revealed highly specific effects of cognitive training on episodic memory. The cognitive training group maintained high levels of enjoyment and motivation to continue after each hour of gameplay, with self-confidence and self-rated memory ability improving over time. Conclusions: Episodic memory robustly improved in the cognitive training group. "Gamified" cognitive training may also enhance visuospatial abilities in patients with amnestic mild cognitive impairment. Gamification maximizes engagement with cognitive training by increasing motivation and could complement pharmacological treatments for amnestic mild cognitive impairment and mild Alzheimer's disease. Larger, more controlled trials are needed to replicate and extend these findings.

Indexed as

Computers, HandheldMemory, EpisodicTherapy, Computer-AssistedAgedAmnesiaAssociation LearningCognitive Behavioral TherapyCognitive DysfunctionFemaleGames, ExperimentalHumansMaleMotivationMultivariate AnalysisNeuropsychological TestsPatient Satisfactioncognitive trainingepisodic memorymild cognitive impairmentmotivationpaired associates learning

Identifiers

PMID28898959
PMCPMC5569993
OpenAlexW2727354882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.