ArticleBritish journal of pharmacology2018
Importance of the second extracellular loop for melatonin MT
Article in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Structure of the melatonin-related orphan receptor, GPR50.Molecules and cells · 2026Article
- GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026Review
- Phylogenetic and Structural Insights into Melatonin Receptors in Plants: Case Study inPlants (Basel, Switzerland) · 2025Article
- Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the GJournal of pineal research · 2025Article
- Design, Synthesis, In Silico Studies and In Vitro Evaluation of New Indole- and/or Donepezil-like Hybrids as Multitarget-Directed Agents for Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Why Are We Still Cloning Melatonin Receptors? A Commentary.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.ACS pharmacology & translational science · 2021Article
- Cryo-EM structure of the human MTNature structural & molecular biology · 2021Article
- Structural insights into melatonin receptors.The FEBS journal · 2020Review
- Phylogenetic Reclassification of Vertebrate Melatonin Receptors To Include Mel1d.G3 (Bethesda, Md.) · 2019Article
- Article
- Melatonin Target Proteins: Too Many or Not Enough?Frontiers in endocrinology · 2019Review
- Recent developments in research of melatonin and its potential therapeutic applications.British journal of pharmacology · 2018Article
- Importance of the second extracellular loop for melatonin MTBritish journal of pharmacology · 2018Article
- Hamster Melatonin Receptors: Cloning and Binding Characterization of MT₁ and Attempt to Clone MT₂.International journal of molecular sciences · 2018Article
- Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus).PloS one · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeRecent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand binding and gating and receptor activation. Here, we have assessed the role of the E2 loop in the activation of the melatonin MT EXPERIMENTAL APPROACH: Chimeric MT KEY
resultsMD simulations of 300 ns revealed (i) the tight hairpin structure of the E2 loop of the MT CONCLUSIONS AND IMPLICATIONS: Our work demonstrated the crucial role of the E2 loop for MT LINKED ARTICLES: This article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.