Evidence map›Paper›PMID 28898692›Full record

ArticleCancer cell2017

Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation.

Susan J Clark, Peter L Molloy

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cancer cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. NCancer communications (London, England) · 2021
    Review
  4. mCancer cell · 2020
    Review
  5. Effects of Inhaled Tobacco Smoke on the Pulmonary Tumor Microenvironment.Advances in experimental medicine and biology · 2020
    Review
  6. Dynamic mOncogene · 2019
    Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Susan J ClarkEpigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 1466, Australia. Electronic address: s.clark@garvan.org.au.
Peter L MolloyCSIRO Health and Biosecurity, PO Box 52, North Ryde, NSW 1670, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How genetic and epigenetic events synergize to generate the oncogenic state is not well understood. In this issue of Cancer Cell, Vaz et al. provide compelling evidence that exposure to chronic cigarette smoke causes progressive epigenetic alterations that prime for key genetic events to drive the development of lung cancer.

Indexed as

NicotianaSmokeCarcinogenesisHumansLungLung NeoplasmsMutationSmoke

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.