ArticleJournal of the American Geriatrics Society2017
Racial Differences in the Association Between Apolipoprotein E Risk Alleles and Overall and Total Cardiovascular Mortality Over 18 Years.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Alcohol use andAlzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Deviations from additivity in APOE4-mediated late-onset Alzheimer's disease risk across races and ethnicities.Human genetics · 2026Article
- Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Leveraging undecided cases in chart-reviewed phenotypes to enhance EHR-based association studies.Journal of biomedical informatics · 2025Article
- Proteins linking APOE ɛ4 with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- 2024 Alzheimer's disease facts and figures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults.Neurology · 2024Article
- Serum total tau, neurofilament light, and glial fibrillary acidic protein are associated with mortality in a population study.Journal of the American Geriatrics Society · 2024Article
- Association between metabolic syndrome and risk of incident dementia in UK Biobank.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebellar EEG source localization reveals age-related compensatory activity moderated by genetic risk for Alzheimer's disease.Psychophysiology · 2023Article
- Leveraging African American family connectors for Alzheimer's disease genomic studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Article
- Contribution of life course cardiovascular risk factors to racial disparities in dementia incidence.Frontiers in dementia · 2023Article
- Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease.Ophthalmology. Retina · 2022Article
- Lipoproteins in the Central Nervous System: From Biology to Pathobiology.Annual review of biochemistry · 2022Review
- Brain health correlates of mobility-related confidence.Experimental gerontology · 2022Observational
- Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men.GeroScience · 2022Article
- Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline.Neurology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo examine the difference in the association between apolipoprotein (APO)E allele and overall and cardiovascular mortality between African Americans (AAs) and European Americans (EAs).
designLongitudinal, cohort study of 18 years.
settingBiracial urban US population sample.
participants4,917, 68% AA and 32% EA. MEASUREMENTS: APOE genotype and mortality based on National Death Index.
resultsA higher proportion of AAs than of EAs had an APOE ε2 allele (ε2ε2/ε2ε3/ε2ε4; 22% vs 13%) and an APOE ε4 allele (ε3ε4/ε4ε4; 33% vs 24%). After adjusting for known risk factors, the risk of mortality was 19% less with the APOE ε2 allele (hazard ratio (HR) = 0.81, 95% confidence interval (CI) = 0.76-0.87), and the risk of cardiovascular mortality was 35% less (HR = 0.65, 95% CI = 0.58-0.76) than with the ε3ε3 allele. The risk of mortality was 10% greater with the APOE ε4 allele (HR = 1.10, 95% CI = 1.04-1.16), and the risk of cardiovascular mortality was 20% greater (HR = 1.20, 95% CI = 1.07-1.29) than with the ε3ε3 allele. No difference in the association between APOE allele and mortality was observed between AAs and EAs.
conclusionThe APOE ε4 allele increased the risk of overall and cardiovascular mortality, whereas the APOE ε2 allele decreased the risk of overall and cardiovascular mortality. There was no racial difference in the association between these alleles and mortality.
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