ArticlePloS one2017
Association between retinal vein occlusion and an increased risk of acute myocardial infarction: A nationwide population-based follow-up study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.Journal of cardiovascular development and disease · 2025Review
- The Use of Retinal Imaging Including Fundoscopy, OCT, and OCTA for Cardiovascular Risk Stratification and the Detection of Subclinical Atherosclerosis.Current atherosclerosis reports · 2025Review
- Is retinal vein occlusion highly associated with an increased risk of myocardial infarction? A systematic review and meta-analysis.International journal of retina and vitreous · 2024Review
- Distinctive Imaging Characteristics of Retinal and Cerebral Vessels between Central and Branch Retinal Vein Occlusion by MRI and AI-Based Image Analyzer.Diagnostics (Basel, Switzerland) · 2024Article
- Risk of Stroke, Myocardial Infarction, Deep Vein Thrombosis, Pulmonary Embolism, and Death After Retinal Vein Occlusion.American journal of ophthalmology · 2024Article
- [Internistic clarification of retinal vascular occlusions].Die Ophthalmologie · 2023Article
- Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques.Journal of personalized medicine · 2023Review
- Cardiovascular morbidity and all-cause mortality in patients with retinal vein occlusion: a Danish nationwide cohort study.The British journal of ophthalmology · 2023Article
- Impact of statin treatment on cardiovascular events in patients with retinal vein occlusion: a nested case-control study in Korea.Epidemiology and health · 2023Article
- Review: The Development of Risk Factors and Cytokines in Retinal Vein Occlusion.Frontiers in medicine · 2022Review
- Association between retinitis pigmentosa and an increased risk of primary angle closure glaucoma: A population-based cohort study.PloS one · 2022Article
- Article
- Efficacy of Modified Treat-and-Extend Aflibercept Regimen for Macular Edema Due to Branch Retinal Vein Occlusion: 1-Year Prospective Study.Journal of clinical medicine · 2020Article
- Comparison of systemic conditions at diagnosis between central retinal vein occlusion and branch retinal vein occlusion.PloS one · 2019Article
- Association between Central Serous Chorioretinopathy and Risk of Depression: A Population-Based Cohort Study.Journal of ophthalmology · 2019Article
- The association between glaucoma and risk of depression: a nationwide population-based cohort study.BMC ophthalmology · 2018Article
- Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study.Journal of ophthalmology · 2018Article
- The Exposure of Phosphatidylserine Influences Procoagulant Activity in Retinal Vein Occlusion by Microparticles, Blood Cells, and Endothelium.Oxidative medicine and cellular longevity · 2018Article
- Construction and validation of risk prediction models for different subtypes of retinal vein occlusion.Advances in ophthalmology practice and researchArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate a possible association between retinal vein occlusion (RVO) and an increased risk of developing acute myocardial infarction (AMI).
designA population-based retrospective cohort study using the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 1st January, 2001 to 31st December, 2013.
methodsA total of 37921 subjects with RVO were enrolled in the RVO group, and 113763 subjects without RVO were enrolled in the comparison group. The comparison group consisted of randomly selected individuals who were propensity score (PS)-matched with the RVO group at a ratio of 1:3, based on age, gender, obesity, stroke, hyperviscosity syndrome, glaucoma, and the use of antithrombotic drugs. A log-rank test was used to compare the cumulative hazard of AMI between the two groups. A multivariate Cox regression analysis was used to estimate the adjusted hazard ratios (HRs) of AMI, adjusted for PS, diabetes, hypertension, hyperlipidemia, congestive heart failure, and chronic renal failure.
resultsThe mean age of the cohort was 62.4±13.2 years. RVO patients had significantly higher proportions of diabetes, hypertension, hyperlipidemia, congestive heart failure, and chronic renal failure than the comparisons. The mean follow-up period was 5.52 years in the RVO group and 5.55 years in the comparison group (p = 0.16). A log-rank test comparing the cumulative hazard curves of AMI for the two groups revealed a significant difference (p<0.0001). In the multivariate Cox regression after adjustment for PS and confounders, the RVO group had a significantly higher risk of AMI (adjusted HR = 1.21; 95% CI: 1.13 to 1.30). When the RVO group was divided into central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) and analyzed separately, both groups had significantly higher adjusted HRs for developing AMI than the comparison group. Moreover, the CRVO group had a significantly higher risk of AMI than the BRVO group.
conclusionsPeople with RVO are at significantly greater risk of developing AMI than individuals without RVO.
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Registered trials
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