Evidence map›Paper›PMID 28898095›Full record

ArticleOrganic letters2017

Activation of a Cryptic Gene Cluster in Lysobacter enzymogenes Reveals a Module/Domain Portable Mechanism of Nonribosomal Peptide Synthetases in the Biosynthesis of Pyrrolopyrazines.

Shanren Li, Xiuli Wu, Limei Zhang, Yuemao Shen, Liangcheng Du

Abstract read
In one paragraph

Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Nature's Combinatorial Biosynthesis Produces Vatiamides A-F.Angewandte Chemie (International ed. in English) · 2019
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shanren LiState Key Laboratory of Microbial Technology, College of Life Sciences, Shandong University , Jinan 250100, China.
Xiuli WuCollege of Pharmacy, Ningxia Medical University , Yinchuan 750004, China.
Limei Zhang
Yuemao ShenState Key Laboratory of Microbial Technology, College of Life Sciences, Shandong University , Jinan 250100, China.ORCID 0000-0002-3881-0135
Liangcheng DuState Key Laboratory of Microbial Technology, College of Life Sciences, Shandong University , Jinan 250100, China.ORCID 0000-0003-4048-1008
Shandong University · CNNingxia Medical University · CN

Funding

Discovering New Anti-Infective Agents from LysobacterR01AI097260 · NIAID · UNIVERSITY OF NEBRASKA LINCOLN · PI DU, LIANGCHENG · 2012 to 2015
$839k
NIAID NIH HHS R01 AI097260
6 · The paper itself

Abstract

Lysobacter are considered "peptide specialists". However, many of the nonribosomal peptide synthetase genes are silent. Three new compounds were identified from L. enzymogenes upon activating the six-module-containing led cluster by the strong promoter P

Indexed as

Multigene FamilyLysobacterMolecular StructurePeptide SynthasesPeptide Synthases

Identifiers

PMID28898095
PMCPMC5632221
OpenAlexW2754419068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.