ArticleImmunogenetics1987
Interleukin-1 alpha and beta genes: linkage on chromosome 2 in the mouse.
Article in Immunogenetics, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis.Journal of neuroinflammation · 2013Review
- Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury.Journal of neuroinflammation · 2012Article
- Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion.The Journal of experimental medicine · 1998Article
- Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone.The Journal of experimental medicine · 1996Article
- A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1 beta gene.Molecular and cellular biology · 1995Article
- The tight-skin (Tsk) mutation is closely linked to B2m on mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Localization of Shaw-related K+ channel genes on mouse and human chromosomes.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Chromosomal localization of uroplakin genes of cattle and mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Linkage mapping of alpha-2 adrenergic receptor genes to mouse chromosomes 2 and 5.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.Molecular and cellular biology · 1993Article
- Mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- The gene for proliferating cell nuclear antigen (Pcna) maps to mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Mapping of the mouse ornithine decarboxylase-related sequence family.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.The EMBO journal · 1991Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Ras-like genes and gene families in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- A linkage map of distal mouse chromosome 12.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Cloning and expression of a widely expressed receptor tyrosine phosphatase.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Two interleukin-1 polypeptides, alpha and beta, are known, and cDNAs corresponding to each have been described. Genomic cloning and Southern blotting experiments suggest that in the mouse each is encoded by a gene present in one copy per haploid genome. Analysis of a panel of somatic cell hybrids carrying various mouse chromosomes on a constant Chinese hamster background indicates that both genes map to mouse chromosome 2. Further, analysis of the inheritance of DNA restriction fragment length polymorphisms associated with each gene in recombinant inbred strains of mice shows the two loci to be tightly linked to one another, and to lie approximately 4.7 centimorgans distal to B2m (beta-2 microglobulin). We have named the locus encoding IL-1 alpha Il-1 alpha and the locus encoding IL-1 beta Il-1b.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.