Evidence map›Paper›PMID 28895568›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

Response to Targeted Cognitive Training Correlates with Change in Thalamic Volume in a Randomized Trial for Early Schizophrenia.

Ian S Ramsay, Susanna Fryer, Alison Boos, Brian J Roach, Melissa Fisher, Rachel Loewy, Sophia Vinogradov, Daniel H Mathalon

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Article
  11. Article
  12. Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
  13. Synaptic plasticity and mental health: methods, challenges and opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Corticolimbic brain anomalies are associated with cognitive subtypes in psychosis: A longitudinal study.European psychiatry : the journal of the Association of European Psychiatrists · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ian S RamsayDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Susanna FryerDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Alison BoosDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Brian J RoachDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Melissa FisherDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Rachel LoewyDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Sophia VinogradovDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Daniel H MathalonDepartment of Psychiatry, University of California, San Francisco, CA, USA.
University of California, San Francisco · USSan Francisco VA Medical Center · USUniversity of Minnesota · US

Funding

Functional Brain Abnormalities in the Schizophrenia ProdromeR01MH076989 · NIMH · YALE UNIVERSITY · PI MATHALON, DANIEL H · 2007 to 2014
$2.3M
NIMH NIH HHS R01 MH076989
6 · The paper itself

Abstract

Reduced thalamic volume is consistently observed in schizophrenia, and correlates with cognitive impairment. Targeted cognitive training (TCT) of auditory processing in schizophrenia drives improvements in cognition that are believed to result from functional neuroplasticity in prefrontal and auditory cortices. In this study, we sought to determine whether response to TCT is also associated with structural neuroplastic changes in thalamic volume in patients with early schizophrenia (ESZ). Additionally, we examined baseline clinical, cognitive, and neural characteristics predictive of a positive response to TCT. ESZ patients were randomly assigned to undergo either 40 h of TCT (N=22) or a computer games control condition (CG; N=22 s). Participants underwent MRI, clinical, and neurocognitive assessments before and after training (4-month interval). Freesurfer automated segmentation of the subcortical surface was carried out to measure thalamic volume at both time points. Left thalamic volume at baseline correlated with baseline global cognition, while a similar trend was observed in the right thalamus. The relationship between change in cognition and change in left thalamus volume differed between groups, with a significant positive correlation in the TCT group and a negative trend in the CG group. Lower baseline symptoms were related to improvements in cognition and left thalamic volume preservation following TCT. These findings suggest that the cognitive gains induced by TCT in ESZ are associated with structural neuroplasticity in the thalamus. Greater symptom severity at baseline reduced the likelihood of response to TCT both with respect to improved cognition and change in thalamic volume.

Indexed as

Cognitive Behavioral TherapyAuditory PerceptionCognition DisordersFemaleHumansMagnetic Resonance ImagingMaleMemory, Short-TermNeuronal PlasticityOrgan SizeSchizophreniaSchizophrenic PsychologyThalamusTreatment OutcomeYoung Adult

Identifiers

PMID28895568
PMCPMC5770762
OpenAlexW2756313845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.