Evidence map›Paper›PMID 28895532›Full record

ArticleeLife2017

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca

Zhuo Guan, Maria Bykhovskaia, Ramon A Jorquera, Roger Bryan Sutton, Yulia Akbergenova, J Troy Littleton

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Neurotransmitter release is triggered by a calcium-induced rearrangement in the Synaptotagmin-1/SNARE complex primary interface.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Dynamic Formation of the Protein-Lipid Pre-fusion Complex.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. The juxtamembrane linker of synaptotagmin 1 regulates CabioRxiv : the preprint server for biology · 2023
    Article
  12. Review
  13. The Core Complex of the CaJournal of molecular biology · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Zhuo GuanPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
Maria BykhovskaiaDepartment of Neurology, School of Medicine, Wayne State University, Detroit, United States.
Ramon A JorqueraNeuroscience Department, Universidad Central del Caribe, Bayamon, Puerto Rico.ORCID http://orcid.org/0000-0002-5460-1755
Roger Bryan SuttonDepartment of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, United States.
Yulia AkbergenovaPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
J Troy LittletonPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.ORCID http://orcid.org/0000-0001-5576-2887
Institute of Cognitive and Brain Sciences · USCentral University of the Caribbean · PRTexas Tech University · USWayne State University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
CHARACTERIZATION OF THE DROSOPHILA SYNAPTOTAGMIN FAMILYR01NS040296 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LITTLETON, J. TROY · 2000 to 2024
$7.9M
Imaging Synaptic Transmission of Individual Active ZonesR01MH104536 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI J. TROY LITTLETON · 2014 to 2026
$4.7M
Regulation of synaptic vesicle mobilization,priming and recycling by complexinU54NS083924 · NINDS · UNIVERSIDAD CENTRAL DEL CARIBE · PI BYKHOVSKAIA, MARIA · 2013 to 2015
$4.3M
Human dysferlin and its implications in Limb-Girdle Muscular DystrophyR01AR063634 · NIAMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI SUTTON, ROGER BRYAN · 2014 to 2018
$1.8M
Computational and Functional Characterization of the Molecular Steps in Membran*R01MH099557 · NIMH · WAYNE STATE UNIVERSITY · PI BYKHOVSKAIA, MARIA, HUI, CHUNG YUEN · 2012 to 2016
$1.7M
NIAMS NIH HHS R01 AR063634NIH HHS P40 OD018537NIMH NIH HHS R01 MH099557NIMH NIH HHS R01 MH104536NINDS NIH HHS R01 NS040296NINDS NIH HHS U54 NS083924
6 · The paper itself

Abstract

The synaptic vesicle Ca

Indexed as

Membrane FusionAnimalsCalciumCytoplasmic VesiclesDrosophilaSNARE ProteinsSynaptotagminsCalciumSNARE ProteinsSynaptotagminsD. melanogasterexocytosisneuroscienceneurotransmitter releaseSNARE complexsynaptic transmissionsynaptotagmin

Identifiers

PMID28895532
PMCPMC5617632
OpenAlexW2756015487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.