ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018
Strategic infarct location for post-stroke cognitive impairment: A multivariate lesion-symptom mapping study.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.
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Who cites it
93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 208 citations in OpenAlex.
- Ischemic stroke-specific cognitive dysfunction: a bibliometric analysis of research evolution.Frontiers in neurology · 2026Pooled it
- Resting-state functional connectivity alterations in post-stroke cognitive impairment: a systematic review.Brain imaging and behavior · 2025Pooled it
- Immediate and long-term brain activation of acupuncture on ischemic stroke patients: an ALE meta-analysis of fMRI studies.Frontiers in neuroscience · 2024Pooled it
- Effects of exercise therapy on patients with poststroke cognitive impairment: A systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- The effects of the PDE4 inhibitor roflumilast on cognitive performance after a cerebrovascular accident: a double-blind randomized placebo-controlled trial with an open label extension (ROSTMEMA).Journal of psychopharmacology (Oxford, England) · 2026Trial
- How covariate control can bias our insights into brain architecture and pathology.Scientific reports · 2026Article
- Functional connectivity alterations in patients with poststroke cognitive impairment: A resting-state functional magnetic resonance imaging study.World journal of radiology · 2026Article
- Identification of Brain Regions and Networks Critical to Poststroke Cognitive Impairment Through Lesion-symptom and Lesion Network Analyses.Translational stroke research · 2026Article
- Article
- Disrupted intrinsic functional brain topology in patients with basal ganglia ischemic stroke.Quantitative imaging in medicine and surgery · 2025Article
- Atypical Presentation of an Internal Capsule Infarct With Isolated Acute Confusion: A Case Report.Cureus · 2025Article
- Obesity, Hypertension and Brain Health.Current hypertension reports · 2025Review
- Functional connectivity and graph theory of impaired central visual pathways in acute ischemic stroke based on functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Bridging regional neurovascular unit heterogeneity and cognitive function: a review.Fluids and barriers of the CNS · 2025Review
- Intranasal Autologous Conditioned Serum Attenuates Memory Impairment After mPFC Ischemia in Mice.Basic and clinical neuroscience · 2025Article
- A connectome-based functional magnetic resonance imaging study of visuospatial analogical reasoning in stroke.European journal of physical and rehabilitation medicine · 2025Observational
- Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy.Nature communications · 2025Article
- Unravelling the nexus of stroke and dementia: Deciphering the role of secondary neurodegeneration in orchestrating cognitive decline.Neuroprotection (Chichester, England) · 2025Review
- A global effort to benchmark predictive models and reveal mechanistic diversity in long-term stroke outcomes.bioRxiv : the preprint server for biology · 2025Article
- The striatal matrix compartment is expanded in autism spectrum disorder.Journal of neurodevelopmental disorders · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lesion location is an important determinant for post-stroke cognitive impairment. Although several 'strategic' brain regions have previously been identified, a comprehensive map of strategic brain regions for post-stroke cognitive impairment is lacking due to limitations in sample size and methodology. We aimed to determine strategic brain regions for post-stroke cognitive impairment by applying multivariate lesion-symptom mapping in a large cohort of 410 acute ischemic stroke patients. Montreal Cognitive Assessment at three to six months after stroke was used to assess global cognitive functioning and cognitive domains (memory, language, attention, executive and visuospatial function). The relation between infarct location and cognition was assessed in multivariate analyses at the voxel-level and the level of regions of interest using support vector regression. These two assumption-free analyses consistently identified the left angular gyrus, left basal ganglia structures and the white matter around the left basal ganglia as strategic structures for global cognitive impairment after stroke. A strategic network involving several overlapping and domain-specific cortical and subcortical structures was identified for each of the cognitive domains. Future studies should aim to develop even more comprehensive infarct location-based models for post-stroke cognitive impairment through multicenter studies including thousands of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.