Evidence map›Paper›PMID 28895076›Full record

ReviewThe AAPS journal2017

New Botanical Anxiolytics for Use in Companion Animals and Humans.

Rui Liu, Fida Ahmed, Christian Cayer, Martha Mullally, Ana Francis Carballo, Marco Otarola Rojas, Mario Garcia, John Baker, Aleksandar Masic, Pablo E Sanchez and 4 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Publisher
In one paragraph

Review in The AAPS journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03904511 (Safety, Tolerability and Behavioural Effects of Souroubea-Platanus in Healthy Volunteers), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03904511 phase1completednot on this mapstarted 2019, after this paper: background citation

Safety, Tolerability and Behavioural Effects of Souroubea-Platanus in Healthy Volunteers

TypeinterventionalSponsorUniversity of OttawaRan2019 to 2020Enrolled45ConditionsAnxiety, Stress, PsychologicalArmsSouroubea-Platanus Preparation, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Rui LiuDepartment of Biology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
Fida AhmedDepartment of Biology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
Christian CayerUniversity of Ottawa Institute of Mental Health Research, 1145 Carling Ave, Ottawa, Ontario, K1Z 7K4, Canada.
Martha MullallyDepartment of Biology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
Ana Francis CarballoChemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
Marco Otarola RojasHerbario Juvenal Valerio Rodriguez, Facultad de las ciencias de la Tierra y el mar, Universidad Nacional, Heredia, 3000, Costa Rica.
Mario GarciaHerbario Juvenal Valerio Rodriguez, Facultad de las ciencias de la Tierra y el mar, Universidad Nacional, Heredia, 3000, Costa Rica.
John BakerStonehedge Bioresources, Stirling, Ontario, Canada.
Aleksandar MasicCancog Technologies, 120 Carlton Street, Toronto, Ontario, M5A 4K2, Canada.
Pablo E SanchezHerbario Juvenal Valerio Rodriguez, Facultad de las ciencias de la Tierra y el mar, Universidad Nacional, Heredia, 3000, Costa Rica.
Luis PovedaHerbario Juvenal Valerio Rodriguez, Facultad de las ciencias de la Tierra y el mar, Universidad Nacional, Heredia, 3000, Costa Rica.
Zul MeraliUniversity of Ottawa Institute of Mental Health Research, 1145 Carling Ave, Ottawa, Ontario, K1Z 7K4, Canada.
Tony DurstHerbario Juvenal Valerio Rodriguez, Facultad de las ciencias de la Tierra y el mar, Universidad Nacional, Heredia, 3000, Costa Rica.
John T ArnasonDepartment of Biology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada. John.Arnason@uOttawa.ca.
Universidad Nacional · CRUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As part of our ongoing research into botanical therapies for anxiety disorders, the neotropical vine Souroubea sympetala was chosen for study as a phytochemical discovery strategy focusing on rare Central American plant families. When orally administered to male Sprague-Dawley rats, the crude plant extract, its ethyl acetate fraction, supercritical carbon dioxide fraction, or its isolated triterpenes reduced anxiety and/or fear-related behavior in standardized behavioral models. Pharmacological studies showed that the extracts acted at the benzodiazepine GABA

Indexed as

PhytotherapyAnimalsAnti-Anxiety AgentsClinical Trials as TopicDrug StabilityHumansPlant ExtractsRatsRats, Sprague-DawleyReceptors, GABA-AAnti-Anxiety AgentsPlant ExtractsReceptors, GABA-Aanxietycanine noise aversionelevated plus maizeGABAA receptorsouroubea

Identifiers

PMID28895076
OpenAlexW2754962835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.