Evidence map›Paper›PMID 28895067›Full record

ArticleJournal of physiology and biochemistry2017

A GC-MS untargeted metabolomics analysis in the plasma and liver of rats lacking dipeptidyl-peptidase type IV enzyme activity.

Antonio Murgia, Pierluigi Caboni, Erika Cadoni, Monica Serra, Fabio Marongiu, Ezio Laconi

Abstract read
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In one paragraph

Article in Journal of physiology and biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antonio MurgiaDipartimento di Scienze della Vita e dell'Ambiente, Università degli Studi di Cagliari, Via Ospedale 42, 09124, Cagliari, Italy.
Pierluigi CaboniDepartment of Life and Environmental Sciences, University of Cagliari, Via Ospedale 72-09124, Cagliari, Italy. caboni@unica.it.
Erika CadoniDipartimento di Scienze Biomediche, Università degli Studi di Cagliari, Via Porcell 4, 09124, Cagliari, Italy.
Monica SerraDipartimento di Scienze Biomediche, Università degli Studi di Cagliari, Via Porcell 4, 09124, Cagliari, Italy.
Fabio MarongiuDipartimento di Scienze Biomediche, Università degli Studi di Cagliari, Via Porcell 4, 09124, Cagliari, Italy.
Ezio LaconiDipartimento di Scienze Biomediche, Università degli Studi di Cagliari, Via Porcell 4, 09124, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was achieved with the aim to find metabolic changes between Fischer rats with different dipeptidyl peptidase-type 4 (DPPIV) expression. The DPPIV is an enzyme expressed in several tissues and is critically involved in the regulation of meal-related insulin secretion in healthy individuals. The metabolic consequences of chronic DPPIV inhibition were analyzed in a surrogate animal model of genetic enzyme deficiency. Hyphenated gas chromatography-mass spectrometry (GC-MS) and multivariate data analysis techniques were used to study the metabolic aqueous fraction profile of 18 plasma and liver samples in two syngeneic rat strains differing in DPPIV activity (DPPIV

Indexed as

MetabolomicsAnimalsDipeptidyl Peptidase 4LiverRatsDipeptidyl Peptidase 4DPP4 protein, ratDPPIVGlucoseMalic acidPalmitic acid

Identifiers

PMID28895067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.