ArticleJournal of assisted reproduction and genetics2018
Earlier day of blastocyst development is predictive of embryonic euploidy across all ages: essential data for physician decision-making and counseling patients.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pregnancy and perinatal outcomes after day 5 versus day 6 blastocyst-stage embryo transfer: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Day 5 versus Day 6 blastocyst transfers: a systematic review and meta-analysis of clinical outcomes.Human reproduction (Oxford, England) · 2019Pooled it
- The impact of completely shrunken blastocysts on clinical outcomes in vitrified-warmed single blastocyst transfer cycles.Scientific reports · 2025Article
- Assessing the clinical value of day 7 blastocysts: a predictive model for preimplantation genetic testing for aneuploidy (PGT-A) cycles.Journal of assisted reproduction and genetics · 2025Article
- Impact of Transfer Timing on Day-6 Blastocyst Pregnancy Outcomes in HRT Cycles of 2021-2024.International journal of general medicine · 2025Article
- Effects of Various Transfer Strategies of Frozen-Thawed Cleavage-Stage and Blastocyst Embryos on Pregnancy and Neonatal Outcomes in Different Age Groups.Journal of multidisciplinary healthcare · 2025Article
- Preimplantation development analysis of aneuploid embryos with different chromosomal abnormalities.Heliyon · 2024Article
- Preimplantation genetic testing for aneuploidy: predictive embryonic factors.Journal of assisted reproduction and genetics · 2024Article
- Fresh or frozen day 6 blastocyst transfer: is there still a question?Reproductive biology and endocrinology : RB&E · 2024Article
- Single versus double blastocyst transfer in first and second frozen-thawed embryo transfer cycle in advance-aged women: a two-center retrospective cohort study.BMC women's health · 2024Article
- Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A.Scientific reports · 2023Article
- Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer.Scientific reports · 2023Article
- Pregnancy Outcomes for Day 5 Versus Day 6 Single Frozen-thawed Blastocyst Transfer with Different Qualities of Embryos: A Large Matched-cohort Study.Current medical science · 2023Article
- Morphometric assessment of blastocysts: relationship with the ongoing pregnancy rate.F&S reports · 2023Article
- Comparison of clinical outcomes for different morphological scores of D5 and D6 blastocysts in the frozen-thawed cycle.BMC pregnancy and childbirth · 2023Article
- No advantage of single day 6 good-quality blastocyst transfer versus single day 5 poor-quality blastocyst transfer in frozen-thawed cycles stratified by age: a retrospective study.BMC pregnancy and childbirth · 2023Article
- Comparative Embryo Development Outcomes following Extending Embryo Culture to Day 6: A Retrospective Cohort Study.International journal of fertility & sterility · 2023Article
- Great Challenges Remain for niPGT-A Reliability.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Article
- Comparison of day 5 blastocyst with day 6 blastocyst: Evidence from NGS-based PGT-A results.Journal of assisted reproduction and genetics · 2022Article
- The Relationship between Human Embryo Parameters and De Novo Chromosomal Abnormalities in Preimplantation Genetic Testing Cycles.International journal of endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to evaluate whether day of blastocyst development is associated with embryo chromosomal status as determined by high-density oligonucleotide microarray comparative genomic hybridization (aCGH).
methodsThis is a retrospective cohort analysis, including women who underwent in vitro fertilization (IVF) with trophectoderm biopsy at a single private fertility center from January 2014 to December 2014. Repeat cycles were excluded. Cycles were assessed for percentage of blastocysts biopsied on days 5, 6, or 7 and rate of euploid embryos per cycle. Cycles were stratified by Society for Assisted Reproductive Technology (SART) age groups (< 35, 35-37, 38-40, 41-42, > 42) and by donor status.
resultsA total of 388 IVF cycles and 2132 biopsied blastocysts were evaluated. The percentages of blastocysts biopsied on days 5, 6, and 7 were 62.5, 35.8, and 1.7%, respectively. Blastocyst euploid rates on days 5, 6, and 7 were 49.5, 36.5, and 32.9%, respectively. Earlier blastocyst development was associated with a significantly increased euploid rate (p < 0.0001). Younger maternal age (p < 0.0001) and higher number of blastocysts biopsied per patient (p = 0.0063) were both independently associated with greater percentage of euploidy.
conclusionsEarlier blastocyst development is independently associated with a higher likelihood of embryonic euploidy in both autologous and donor embryos. In non-biopsied embryos, these data support selection of day 5 blastocysts for transfer over later-developing embryos. These results can assist with patient counseling regarding expectations and outcomes. To our knowledge, this is the first study to examine embryonic euploidy as stratified by both day of blastocyst development and SART age group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.