ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2017
Efficacy of hemofiltration with PEPA membrane for IL-6 removal in a rat sepsis model.
Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Continuous Hemofiltration During Extracorporeal Membrane Oxygenation in Adult Septic Shock: A Comparative Cohort Analysis.Biomedicines · 2025Article
- Hemoadsorption and plasma adsorption: two current options for the 3rd dimension of dialysis purification.Journal of nephrology · 2025Review
- Utilizing plasma exchange for severe cytokine release syndrome after CAR-T cell therapy: clinical experience and literature insights.Frontiers in immunology · 2025Review
- A model of hemodialysis after acute kidney injury in rats.Intensive care medicine experimental · 2023Article
- Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies?Journal for immunotherapy of cancer · 2020Review
- Hemofiltration in Patients with Severe Acute Pancreatitis (Review).Sovremennye tekhnologii v meditsine · 2020Review
- Journal of Artificial Organs 2017: the year in review : Journal of Artificial Organs Editorial Committee.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2018Review
- Hemofiltration Successfully Eliminates Severe Cytokine Release Syndrome Following CD19 CAR-T-Cell Therapy.Journal of immunotherapy (Hagerstown, Md. : 1997)Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, intensive care physicians have focused on continuous hemodiafiltration with a cytokine-adsorbing hemofilter in the treatment of sepsis. We aimed to establish extracorporeal circulation in a rat sepsis model to evaluate the cytokine removal properties of mini-modules using two types of membrane materials. Rats were divided into polyester polymer alloy (PEPA) and cellulose triacetate (CTA) groups as membrane materials of mini-modules. One hour after 0.1 mg/kg of lipopolysaccharide administration, continuous hemofiltration (CHF) was started in each group. Plasma interleukin-6 (IL-6), an important mediator of sepsis, was measured over time during hemofiltration. The peak IL-6 concentration in PEPA group was approximately 13,000 pg/mL, in comparison to approximately 31,000 pg/mL in CTA group. IL-6 clearance in PEPA group was much more than CTA group. Since IL-6 was not detected in the filtrate in PEPA group, it was considered that IL-6 was adsorbed to the membrane. In conclusion, our results suggest that CHF with PEPA hemofilter can be suitable for removing IL-6 from the blood stream efficiently.
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Registered trials
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