ReviewSeminars in immunopathology2017
Tissue compartmentalization of T cell responses during early life.
Review in Seminars in immunopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells.Nature immunology · 2026Article
- T-cell distribution in the dorsal root ganglion across species, sex, and age.bioRxiv : the preprint server for biology · 2026Article
- Formation of gut microbiota and application of microecological regulators in children.Translational pediatrics · 2025Review
- Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood.Immunity · 2023Article
- Are homeostatic mechanisms aiding the reconstitution of the T-cell pool during lymphopenia in humans?Frontiers in immunology · 2022Review
- Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen.Mucosal immunology · 2021Article
- The Mechanism of PEDV-Carrying CD3Viruses · 2021Article
- PEDV infection in neonatal piglets through the nasal cavity is mediated by subepithelial CD3Veterinary research · 2021Article
- T Cell Subsets During Early Life and Their Implication in the Treatment of Childhood Acute Lymphoblastic Leukemia.Frontiers in immunology · 2021Review
- Article
- Host Microbe Interactions in the Lactating Mammary Gland.Frontiers in microbiology · 2019Review
- Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy.Mucosal immunology · 2018Review
- Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Immunity and immunopathology in early human life.Seminars in immunopathology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The immune system in early life is tasked with transitioning from a relatively protected environment to one in which it encounters a wide variety of innocuous antigens and dangerous pathogens. The immaturity of the developing immune system, and particularly the distinct functionality of T lymphocytes in early life, has been implicated in increased susceptibility to infection. Previous work has demonstrated that immune responses in early life are skewed toward limited inflammation and atopy; however, there is mounting evidence that such responses are context- and tissue-dependent. The regulation, differentiation, and maintenance of infant T cell responses, particularly as it relates to tissue compartmentalization, remains poorly understood. How the tissue environment impacts early-life immune responses and whether the development of localized protective immune memory cell subsets are established is an emerging area of research. As infectious diseases affecting the respiratory and digestive tracts are a leading cause of morbidity and mortality worldwide in infants and young children, a deeper understanding of site-specific immunity is essential to addressing these challenges. Here, we review the current paradigms of T cell responses during infancy as they relate to tissue localization and discuss implications for the development of vaccines and therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.