ReviewEuropean archives of psychiatry and clinical neuroscience2018
Chronobiological theories of mood disorder.
Review in European archives of psychiatry and clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 94 citations in OpenAlex.
- Social Rhythms, Depressive Symptoms, and Quality of Life: An Unbreakable Bond in an Older Adult Sample.International journal of environmental research and public health · 2026Observational
- Nervous and immune system crosstalk shapes cancer progression and treatment response.Discover oncology · 2026Review
- Association between the Alpha-1-acid glycoprotein concentrations and depression in US adult women: a cross-sectional study from NHANES 2021-2023.Frontiers in psychiatry · 2025Article
- From East to West: Regional Disparities in Depressive and Anxious Symptoms Among Chinese Adolescents.Psychology research and behavior management · 2025Article
- Impact of Circadian Rhythm Disturbance and Chronotype on Medical Students' Mental State.Basic and clinical neuroscience · 2025Article
- Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review.Reviews in cardiovascular medicine · 2025Review
- Resilience to Chronic Stress Is Characterized by Circadian Brain-Liver Coordination.Biological psychiatry global open science · 2024Article
- Recent Progress in Biosensors for Depression Monitoring-Advancing Personalized Treatment.Biosensors · 2024Review
- The Use of Melatoninergic Antidepressants for Stabilization of Remission in Depression Comorbid with Alcohol Abuse, Anxiety or Neuropsychiatric Disorders: A Systematic Review.Consortium psychiatricum · 2024Review
- Patient-reported outcomes on sleep quality and circadian rhythm during treatment with intravenous ketamine for treatment-resistant depression.Therapeutic advances in psychopharmacology · 2024Article
- The relationship between self-assessment living standard and mental health among the older in rural China: the mediating role of sleep quality.BMC public health · 2023Article
- Morningness-eveningness preference and shift in chronotype during COVID-19 as predictors of mood and well-being in university students.Personality and individual differences · 2022Article
- Protocol for Characterization of Addiction and Dual Disorders: Effectiveness of Coadjuvant Chronotherapy in Patients with Partial Response.Journal of clinical medicine · 2022Article
- Rapid-acting antidepressants and the circadian clock.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Non-REM sleep in major depressive disorder.NeuroImage. Clinical · 2022Article
- Decrease in Social Zeitgebers Is Associated With Worsened Delayed Sleep-Wake Phase Disorder: Findings During the Pandemic in Japan.Frontiers in psychiatry · 2022Article
- COVID-19 related poor mental health and sleep disorders in rheumatic patients: a citizen science project.BMC psychiatry · 2021Article
- Review
- Sooner than you think: A very early affective reaction to the COVID-19 pandemic and quarantine in Argentina.Journal of affective disorders · 2021Article
- Linking Depression to Epigenetics: Role of the Circadian Clock.Advances in experimental medicine and biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading cause of disability, affecting approximately 100 million adults worldwide. The disorder is characterized by a constellation of symptoms affecting mood, anxiety, neurochemical balance, sleep patterns, and circadian and/or seasonal rhythm entrainment. However, the mechanisms underlying the association between chronobiological parameters and depression remain unknown. A PubMed search was conducted to review articles from 1979 to the present, using the following search terms: "chronobiology," "mood," "sleep," and "circadian rhythms." We aimed to synthesize the literature investigating chronobiological theories of mood disorders. Current treatments primarily include tricyclic antidepressants and selective serotonin reuptake inhibitors, which are known to increase extracellular concentrations of monoamine neurotransmitters. However, these antidepressants do not treat the sleep disturbances or circadian and/or seasonal rhythm dysfunctions associated with depressive disorders. Several theories associating sleep and circadian rhythm disturbances with depression have been proposed. Current evidence supports the existence of associations between these, but the direction of causality remains elusive. Given the existence of chronobiological disturbances in depression and evidence regarding their treatment in improving depression, a chronobiological approach, including timely use of light and melatonin agonists, could complement the treatment of MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.