Evidence map›Paper›PMID 28894884›Full record

ArticleClinical neuroradiology2019

Characterization of Skull Base Lesions Using Pseudo-Continuous Arterial Spin Labeling.

B Geerts, D Leclercq, S Tezenas du Montcel, B Law-Ye, S Gerber, D Bernardeschi, D Galanaud, D Dormont, N Pyatigorskaya

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Article in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

B GeertsGroupe Hospitalier Pitié-Salpêtrière, Neuroradiology department, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France.
D LeclercqGroupe Hospitalier Pitié-Salpêtrière, Neuroradiology department, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France.
S Tezenas du MontcelGroupe Hospitalier Pitié-Salpêtrière, Biostatistics Unit, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France.
B Law-YeGroupe Hospitalier Pitié-Salpêtrière, Neuroradiology department, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France.
S GerberGroupe Hospitalier Pitié-Salpêtrière, Neuroradiology department, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France.
D BernardeschiGroupe Hospitalier Pitié-Salpêtrière, Otology, auditory implants and skull base surgery department, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France.
D GalanaudGroupe Hospitalier Pitié-Salpêtrière, Neuroradiology department, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France.
D DormontGroupe Hospitalier Pitié-Salpêtrière, Neuroradiology department, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France.
N PyatigorskayaGroupe Hospitalier Pitié-Salpêtrière, Neuroradiology department, AP-HP, 47-83 bd de l'Hôpital, 75651, Paris, France. nadya.pyatigorskaya@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePseudo-continuous arterial spin labeling (pCASL) is a non-invasive magnetic resonance (MR) perfusion technique. Our study aimed at estimating the diagnostic performance of the pCASL sequence in assessing the perfusion of skull base lesions both qualitatively and quantitatively and at providing cut-off values for differentiation of specific skull base lesions.

methodsIn this study 99 patients with histopathologically confirmed skull base lesions were retrospectively enrolled. Based on a pathological analysis, the lesions were classified as hypervascular and non-hypervascular. Patients were divided into two subgroups according to the anatomical origin of each lesion. The MRI study included pCASL and 3D T1-weighted fat-saturated post-contrast sequences. Of the patients seven were excluded due to technical difficulties or patient movement. The lesions were classified by two raters, blinded to the diagnosis as either hyperperfused or non-hyperperfused, based on the pCASL sequence. The normalized tumor blood flow (nTBF) of each lesion was determined. Qualitative and quantitative characteristics of hypervascular and non-hypervascular lesions were compared.

resultsVisual assessment enabled correct classification of 98% of the lesions to be performed. Quantitatively, we found significant differences between the nTBF values for hypervascular and non-hypervascular lesions (p < 0.001) and provided cut-off values, allowing meningioma and schwannoma to be distinguished from meningioma and adenoma. Significant differences were also found within the hypervascular group, namely, paraganglioma was more hyperperfused than meningioma (p = 0.003) or metastases (p = 0.009).

conclusionThe present study demonstrates the high diagnostic performance of pCASL in characterizing skull base lesions by either visual assessment or nTBF quantification. Adding the pCASL sequence to the conventional protocol of skull base assessment can be recommended.

Indexed as

AdenomaAdultAgedContrast MediaDiagnosis, DifferentialFemaleHumansMagnetic Resonance ImagingMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeurilemmomaNeuroma, AcousticOrbital NeoplasmsPituitary NeoplasmsContrast MediaSpin LabelsArterial spin labelingMagnetic resonance imagingPerfusionSkull base lesions

Identifiers

PMID28894884

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.