ArticleLaryngoscope investigative otolaryngology2016
Evaluation of peripheral nerve regeneration through biomaterial conduits via micro-CT imaging.
Article in Laryngoscope investigative otolaryngology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Newly Designed PCL-Wrapped Cryogel-Based Conduit Activated with IKVAV Peptide Derivative for Peripheral Nerve Repair.Pharmaceutics · 2024Article
- Nerve Regeneration with a Scaffold Incorporating an Absorbable Zinc-2% Iron Alloy Filament to Improve Axonal Guidance.Pharmaceutics · 2023Article
- Effects of Altering Magnesium Metal Surfaces on Degradation In Vitro and In Vivo during Peripheral Nerve Regeneration.Materials (Basel, Switzerland) · 2023Article
- Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications.Polymers · 2022Review
- Improvement of sciatic nerve regeneration by multichannel nanofibrous membrane-embedded electro-conductive conduits functionalized with laminin.Journal of materials science. Materials in medicine · 2022Article
- Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications.Materials today. Bio · 2022Review
- Micro-computed tomography utility for estimation of intraparenchymal spinal cord cystic lesions in small animals.Neural regeneration research · 2021Article
- Application of custom anatomy-based nerve conduits on rabbit sciatic nerve defects:Neural regeneration research · 2019Article
- Smart Hydrogels in Tissue Engineering and Regenerative Medicine.Materials (Basel, Switzerland) · 2019Review
- Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration.Biomaterials science · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHollow nerve conduits made of natural or synthetic biomaterials are used clinically to aid regeneration of peripheral nerves damaged by trauma or disease. To support healing, conduit lumen patency must be maintained until recovery occurs. New methods to study conduit structural integrity would provide an important means to optimize conduits in preclinical studies. We explored a novel combined technique to examine structural integrity of two types of nerve conduits after in vivo healing. STUDY
designMicro-CT imaging with iodine contrast was combined with histological analysis to examine two different nerve conduits after in vivo nerve reconstruction in rats. MATERIALS AND
methodsSciatic nerve gaps in adult Lewis rats were reconstructed with poly(caprolactone) (PCL, 1.6 cm gap, 14-week survival) or silicone (1 cm gap, 6-week survival) conduits (N = 12 total). Conduits with regenerating tissues were imaged by micro-CT with iodine contrast and compared to the histology (hematoxylin and eosin, immunostaining for axons) of regenerated tissues after iodine removal.
resultsPCL nerve conduits showed extensive breakage throughout their length, but all showed successful nerve growth through the conduits. The silicone conduits remained intact, although significant constriction was uniquely detected by micro-CT, with 1 of 6 animals showing incomplete tissue regeneration.
conclusionsMicro-CT with iodine contrast offers a unique and valuable means to determine 3D structural integrity of nerve conduits and nerve healing following reconstruction. Furthermore, this paper shows that even if conduit compression and degradation occur, nerve regeneration can still take place.
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Registered trials
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