Evidence map›Paper›PMID 28894802›Full record

ArticleLaryngoscope investigative otolaryngology2016

Adipose-Derived Mesenchymal Stem Cell Features in Patients with a History of Head and Neck Radiation.

Serban San-Marina, Steve Voss, Ruben Crespo-Diaz, Cody Wyles, Atta Behfar, Paul Stalboeger, Jeffrey R Janus

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Serban San-MarinaDepartment of Otolaryngology, Head and Neck Surgery (s.s-m., s.v., j.r.j.) Mayo Clinic Rochester Minnesota U.S.A.
Steve VossDepartment of Otolaryngology, Head and Neck Surgery (s.s-m., s.v., j.r.j.) Mayo Clinic Rochester Minnesota U.S.A.
Ruben Crespo-DiazDepartment of Cardiology (r.c-d., a.b., p.s.) Mayo Clinic Rochester Minnesota U.S.A.
Cody WylesMayo Medical School (c.w.); Mayo Clinic Rochester Minnesota U.S.A.
Atta BehfarDepartment of Cardiology (r.c-d., a.b., p.s.) Mayo Clinic Rochester Minnesota U.S.A.
Paul StalboegerDepartment of Cardiology (r.c-d., a.b., p.s.) Mayo Clinic Rochester Minnesota U.S.A.
Jeffrey R JanusDepartment of Otolaryngology, Head and Neck Surgery (s.s-m., s.v., j.r.j.) Mayo Clinic Rochester Minnesota U.S.A.
Mayo Clinic in Florida · USMayo Clinic · USMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectives/hypothesisRadiation plays a prominent role in advanced stage head and neck tumors. Often, the radiated area includes adjacent nonmalignant mesenchymal tissue, which contains a mixture of cells that has been shown to accelerate wound healing. The purpose of this study is to determine the long-term effect of radiation on the expansion potential of adipose-derived stromal/stem cell (ADSC) tissue and on the ability of resident stem cells in this fraction to undergo phenotypic differentiation. Study Design/Methods: After institutional review board approval, 12 patients with a history of head and neck radiation and pending surgery were enrolled. Adipose tissue was collected from irradiated tissue (XRT) and nonirradiated tissue (NRT) sites. Mesenchymal stem cells were isolated from these populations, with subsequent assessment of cellular kinetics and differentiation potential between harvest sites.

resultsAdipose-derived stromal/stem cells could not be isolated from XRT in six patients due to lack of in vitro cell proliferation. For the remaining six patients, overall cumulative population-doubling time was longer for XRT relative to NRT (29.3 vs. 11.5 days;

conclusionThese preliminary observations suggest that irradiated ADSCs close to the surgical site undergo long-term changes in proliferative capacity. The potential for phenotypic differentiation is retained, however, in ADSCs that survive the irradiation process. LEVEL OF EVIDENCE: 2b.

Indexed as

adipose‐derived stem celldifferentiationphenotypicradiationRegenerative medicinestem cell

Identifiers

PMID28894802
PMCPMC5510263
OpenAlexW2410043007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.