Evidence map›Paper›PMID 28894700›Full record

ArticleFrontiers in cellular and infection microbiology2017

Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors.

Ursula Waack, Tanya L Johnson, Khalil Chedid, Chuanwu Xi, Lyle A Simmons, Harry L T Mobley, Maria Sandkvist

Open access · goldAbstract readValidation Study
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. A decade of genomic and phenotypic adaptation of carbapenem-resistantFrontiers in cellular and infection microbiology · 2025
    Article
  6. Uncovering the Secretion Systems ofAntibiotics (Basel, Switzerland) · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Mechanisms ProtectingInternational journal of molecular sciences · 2020
    Review
  12. Review
  13. Article
  14. IC-2 Suppresses Proliferation and Induces Apoptosis of Bladder Cancer Cells via the Wnt/β-Catenin Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  15. Review
  16. Pathogenomics of Virulence Traits ofFrontiers in microbiology · 2018
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ursula WaackDepartment of Microbiology and Immunology, University of Michigan Medical SchoolAnn Arbor, MI, United States.
Tanya L JohnsonDepartment of Microbiology and Immunology, University of Michigan Medical SchoolAnn Arbor, MI, United States.
Khalil ChedidDepartment of Microbiology and Immunology, University of Michigan Medical SchoolAnn Arbor, MI, United States.
Chuanwu XiDepartment of Environmental Health Sciences, University of Michigan School of Public HealthAnn Arbor, MI, United States.
Lyle A SimmonsDepartment of Molecular, Cellular, and Developmental Biology, University of MichiganAnn Arbor, MI, United States.
Harry L T MobleyDepartment of Microbiology and Immunology, University of Michigan Medical SchoolAnn Arbor, MI, United States.
Maria SandkvistDepartment of Microbiology and Immunology, University of Michigan Medical SchoolAnn Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

Organization and Function of a Type II Secretion ComplexR01AI049294 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDKVIST, MARIA B · 2002 to 2012
$2.9M
Supplement: DNA REPLICATION AND GENOME STABILITYR01GM107312 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMMONS, LYLE · 2013 to 2017
$1.5M
Genome-wide identification of virulence genes in Acinetobacter baumannii in vivoR21AI107184 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOBLEY, HARRY L. · 2014 to 2015
$428k
Organization and function of a type II secretion complexR56AI049294 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDKVIST, MARIA B · 2015 to 2015
$393k
NIAID NIH HHS R01 AI049294NIAID NIH HHS R21 AI107184NIAID NIH HHS R56 AI049294NIGMS NIH HHS R01 GM107312
6 · The paper itself

Abstract

Nosocomial pathogens that develop multidrug resistance present an increasing problem for healthcare facilities. Due to its rapid rise in antibiotic resistance,

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsBacteremiaBacterial ProteinsComplement Factor BDrug Resistance, MultipleEnzyme InhibitorsGenetic FitnessHigh-Throughput Screening AssaysHumansLactonesOrlistatPilot ProjectsReproducibility of ResultsSmall Molecule LibrariesType II Secretion SystemsBacterial ProteinsComplement Factor Bebelactone BEnzyme InhibitorsLactonesLipA protein, BacteriaOrlistatSmall Molecule LibrariesType II Secretion SystemsAcinetobacter baumanniiantibiotic resistanceantidepressantshigh-throughput screeningLipAlipase activitysmall molecule inhibitorstype II secretion

Identifiers

PMID28894700
PMCPMC5581314
OpenAlexW2745703157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.