ArticleMolecular and clinical oncology2017
Giant gastrointestinal stromal tumor of the vermiform appendix: A case report.
Article in Molecular and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Appendiceal Gastrointestinal Stromal Tumor: A Case Report and Review of the Relevant Literature.Cureus · 2026Article
- Incidental finding of gastrointestinal stromal tumor in appendix.Journal of surgical case reports · 2026Article
- A gastrointestinal stromal tumour in the distal ileum-a rare presentation in Saudia Arabia: case report.Frontiers in surgery · 2026Article
- An Incidental Finding of Appendiceal Gastrointestinal Stromal Tumor with Abundant Skeinoid Fibers: A Rare Case Report with Insights from a Comprehensive Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
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Abstract
Gastrointestinal stromal tumors (GISTs) of the vermiform appendix are rare, measuring <3 cm in 82.4% of the reported cases. Neoadjuvant therapy with the receptor tyrosine kinase inhibitor imatinib mesylate has the potential to improve resectability and organ preservation rates in locally advanced or metastatic/recurrent GISTs. We herein report the case of a 67-year-old male patient with an unusually large GIST (22 cm in diameter) of uncertain origin in the right lower abdominal quadrant, with a solitary peritoneal metastasis. Due to the size of this GIST and presence of metastatic disease, neoadjuvant therapy with imatinib (400 mg/day orally) was administered. Follow-up imaging studies revealed marked shrinkage of the primary and metastatic tumors. Subsequently, laparoscopic exploration revealed that the main tumor originated from the tip of the vermiform appendix, and that the peritoneal metastasis was located in the ascending mesocolon. The patient underwent laparoscopic appendectomy and excision of the peritoneal metastasis, without tumor rupture. Therefore, in appropriately selected patients, neoadjuvant imatinib for borderline resectable or oligometastatic GISTs may be a reasonable choice.
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