Evidence map›Paper›PMID 28894513›Full record

ArticleCurrent breast cancer reports2017

Diagnostic Methods, Risk Factors, Prevention, and Management of Breast Cancer-Related Lymphedema: Past, Present, and Future Directions.

Hoda E Sayegh, Maria S Asdourian, Meyha N Swaroop, Cheryl L Brunelle, Melissa N Skolny, Laura Salama, Alphonse G Taghian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current breast cancer reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Financial toxicity experienced by patients with breast cancer-related lymphedema: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. The association between allostatic load and lymphedema in breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hoda E SayeghDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
Maria S AsdourianDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
Meyha N SwaroopDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
Cheryl L BrunelleDepartment of Physical Therapy, Massachusetts General Hospital, Boston, MA, USA.
Melissa N SkolnyDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
Laura SalamaDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
Alphonse G TaghianDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
Massachusetts General Hospital · US

Funding

Early Detection and Treatment of Lymphedema in Women with Breast CancerR01CA139118 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TAGHIAN, ALPHONSE G · 2009 to 2013
$1.4M
NCI NIH HHS R01 CA139118
6 · The paper itself

Abstract

purpose of reviewBreast cancer-related lymphedema (BCRL) is a chronic, adverse, and much feared complication of breast cancer treatment, which affects approximately 20% of patients following breast cancer treatment. BCRL has a tremendous impact on breast cancer survivors, including physical impairments and significant psychological consequences. The intent of this review is to discuss recent studies and analyses regarding the risk factors, diagnosis, prevention through early screening and intervention, and management of BCRL. RECENT

findingsHighly-evidenced risk factors for BCRL include axillary lymph node dissection, lack of reconstruction, radiation to the lymph nodes, high BMI at diagnosis, weight fluctuations during and after treatment, subclinical edema within and beyond 3 months after surgery, and cellulitis in the at-risk arm. Avoidance of potential risk factors can serve as a method of prevention. Through establishing a screening program by which breast cancer patients are measured pre-operatively and at follow-ups, are objectively assessed through a weight-adjusted analysis, and are clinically assessed for signs and symptoms, BCRL can be tracked accurately and treated effectively. Management of BCRL is done by a trained professional, with research mounting towards the use of compression bandaging as a first line intervention against BCRL. Finally, exercise is safe for breast cancer patients with and without BCRL and does not incite or exacerbate symptoms of BCRL. SUMMARY: Recent research has shed light on BCRL risk factors, diagnosis, prevention, and management. We hope that education on these aspects of BCRL will promote an informed, consistent approach and encourage additional research in this field to improve patient outcomes and quality of life in breast cancer survivors.

Indexed as

Breast cancer-related lymphedemaDiagnosisManagementPreventionRisk factorsSurvivorship

Identifiers

PMID28894513
PMCPMC5590641
OpenAlexW2610456020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.