Evidence map›Paper›PMID 28894464›Full record

ArticleGastroenterology research and practice2017

Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization.

A Rebonato, L Graziosi, D Maiettini, E Marino, V De Angelis, L Brunese, S Mosca, G Metro, M Rossi, G Orgera and 2 more

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Article in Gastroenterology research and practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. CIRSE Standards of Practice on Hepatic Transarterial Chemoembolisation.Cardiovascular and interventional radiology · 2021
    Article
  9. Article
  10. Article
  11. Observational
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

A RebonatoDepartment of Radiology, University of Perugia, Perugia, Italy.
L GraziosiDepartment of General and Emergency Surgery, University of Perugia, Perugia, Italy.
D MaiettiniDepartment of Radiology, University of Perugia, Perugia, Italy.
E MarinoDepartment of General and Emergency Surgery, University of Perugia, Perugia, Italy.ORCID 0000-0001-8454-503X
V De AngelisDepartment of Medical Oncology, University of Perugia, Perugia, Italy.
L BruneseDepartment of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
S MoscaDepartment of Radiology, University of Perugia, Perugia, Italy.
G MetroDepartment of Medical Oncology, University of Perugia, Perugia, Italy.
M RossiDepartment of Interventional Radiology, University La Sapienza, Rome, Italy.
G OrgeraDepartment of Interventional Radiology, University La Sapienza, Rome, Italy.
M ScialpiDepartment of Radiology, University of Perugia, Perugia, Italy.
A DoniniDepartment of General and Emergency Surgery, University of Perugia, Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTransarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated whether preoperative inflammatory factors such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio affected our patient survival when affected by hepatocellular carcinoma.

methodsWe retrospectively evaluated a total of 72 patients with hepatocellular carcinoma that underwent TACE. We enrolled patients with different etiopathogeneses of hepatitis and histologically proven HCC not suitable for surgery. The overall study population was dichotomized in two groups according to the median NLR value and was analyzed also according to other prognostic factors.

resultsThe global median overall survival (OS) was 28 months. The OS in patients with high NLR was statistically significantly shorter than that in patients with low NLR. The following pretreatment variables were significantly associated with the OS in univariate analyses: age, Child-Pugh score, BCLC stage, INR, and NLR. Pretreated high NLR was an independently unfavorable factor for OS.

conclusionNLR could be considered a good prognostic factor of survival useful to stratify patients that could benefit from TACE treatment.

Identifiers

PMID28894464
PMCPMC5574298

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