Evidence map›Paper›PMID 28894423›Full record

ArticleFrontiers in physiology2017

β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia.

Shannon R Murphy, Lianguo Wang, Zhen Wang, Philip Domondon, Di Lang, Beth A Habecker, Rachel C Myles, Crystal M Ripplinger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Role of Reduced Sarco-Endoplasmic Reticulum CaFrontiers in physiology · 2021
    Article
  3. Article
  4. Oxidation of ryanodine receptor after ischemia-reperfusion increases propensity of CaAmerican journal of physiology. Heart and circulatory physiology · 2018
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Shannon R MurphyDepartment of Pharmacology, University of California, DavisDavis, CA, United States.
Lianguo WangDepartment of Pharmacology, University of California, DavisDavis, CA, United States.
Zhen WangDepartment of Pharmacology, University of California, DavisDavis, CA, United States.
Philip DomondonDepartment of Biomedical Engineering, University of California, DavisDavis, CA, United States.
Di LangDepartment of Pharmacology, University of California, DavisDavis, CA, United States.
Beth A HabeckerDepartment of Physiology and Pharmacology, Oregon Health & Science UniversityPortland, OR, United States.
Rachel C MylesInstitute of Cardiovascular and Medical Sciences, University of GlasgowGlasgow, United Kingdom.
Crystal M RipplingerDepartment of Pharmacology, University of California, DavisDavis, CA, United States.
University of California, Davis · USOregon Health & Science University · USUniversity of Glasgow · GB

Funding

Neurotrophins and post-infarct plasticity in cardiac sympathetic neuronsR01HL093056 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETH A HABECKER · 2009 to 2026
$7.9M
The Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1M
NHLBI NIH HHS R01 HL093056NHLBI NIH HHS R01 HL111600Wellcome Trust
6 · The paper itself

Abstract

β-adrenergic receptor (β-AR) blockers may be administered during acute myocardial infarction (MI), as they reduce energy demand through negative chronotropic and inotropic effects and prevent ischemia-induced arrhythmogenesis. However, the direct effects of β-AR blockers on ventricular electrophysiology and intracellular Ca

Indexed as

arrhythmiabeta blockercalciumischemiasarcoplasmic reticulum

Identifiers

PMID28894423
PMCPMC5581400
OpenAlexW2749410130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.