ArticleOncoTargets and therapy2017
Initial experience of correlating diffusion spectral parameters with histopathologic indexes in murine colorectal tumor homografts.
Article in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo determine the correlation between continuously distributed diffusion-weighted image (DWI)-derived parameters and histopathologic indexes.
methodsFifty-four mice bearing HCT-116 colorectal tumors were included for analysis; 12 mice were used for continuous observation, and the other 42 mice were used for break-point observation. All mice were randomly divided into radiotherapy and non-radiotherapy groups. Optical imaging and MRI were performed at different time points according to radiotherapy regimen (baseline, 24 h, 48 h, 72 h, 7 d, 14 d, and 28 d). Continuous observation data were analyzed to show the difference of dynamic changing trends of optical and MR-DWI-derived parameters between radiotherapy and non-radiotherapy groups (photon numbers, D_max, full width half maximum [FWHM], and apparent diffusion coefficient [ADC] value). Break-point observation data were used to analyze the correlation between histopathologic indices and DWI-derived parameters.
resultsThere was a significant difference in the changing trends of photon numbers, D_max, FWHM, and ADC value between radiotherapy and non-radiotherapy groups, especially at early time points. There was moderate negative correlation between Ki67 and percentage changes of D_max, FWHM, and ADC values (the correlation coefficients were 0.632, 0.449, and 0.586,
conclusionThe continuously distributed DWI-derived parameters could reflect histological behavior to some extent and, thus, are potential markers for early noninvasive monitoring of tumor cell apoptosis and proliferation.
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