ArticleScientific reports2017
T-cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- LAG3 constrains anti-parasitic response by effector CD4Parasites & vectors · 2026Article
- Analysis of four Echinococcus multilocularis mitogenome sequences from Inner Mongolia, China: supporting the hypothesis that E. sibiricensis is confirmed as the O1 haplotype.Parasites & vectors · 2025Article
- Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host.Cellular and molecular life sciences : CMLS · 2025Article
- The genetic variation of mitochondrial sequences and pathological differences ofMicrobiology spectrum · 2025Article
- GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival.Veterinary research · 2025Article
- Immunological landscape of hepatic alveolar echinococcosis: A bibliometric analysis.World journal of hepatology · 2025Article
- Efficacy and safety of pseudolaric acid B againstFrontiers in medicine · 2025Article
- Upregulation of CD244 promotes CD8Parasites & vectors · 2024Article
- High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis.Parasites & vectors · 2024Article
- Association of IL-9 Cytokines with Hepatic Injury inBiomolecules · 2024Article
- Enhancing the therapeutic potential of P29 protein-targeted monoclonal antibodies in the management of alveolar echinococcosis through CDC-mediated mechanisms.PLoS pathogens · 2024Article
- Targeting myeloid-derived suppressor cells promotes antiparasitic T-cell immunity and enhances the efficacy of PD-1 blockade (15 words).Nature communications · 2024Article
- Immunological Characteristics of Hepatic Dendritic Cells in Patients and Mouse Model with LiverTropical medicine and infectious disease · 2024Article
- Characterization of the immunosuppressive environment induced by larvalInfection and immunity · 2024Article
- Inhibition of the MyD88 signaling pathway could upregulates Ghrelin expression to synergistically regulate hepaticFrontiers in immunology · 2024Article
- Hepatic macrophages play critical roles in the establishment and growth of hydatid cysts in the liver during Echinococcus granulosus sensu stricto infection.PLoS neglected tropical diseases · 2023Article
- Upregulation of LAG3 modulates the immune imbalance of CD4+ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model.PLoS pathogens · 2023Article
- NIR-II fluorescence microscopic bioimaging for intrahepatic angiography and the early detection ofFrontiers in bioengineering and biotechnology · 2023Article
- Single-Cell Heterogeneity of the Liver-Infiltrating Lymphocytes in Individuals with Chronic Echinococcus multilocularis Infection.Infection and immunity · 2022Article
- Primary Infection by E. multilocularis Induces Distinct Patterns of Cross Talk between Hepatic Natural Killer T Cells and Regulatory T Cells in Mice.Infection and immunity · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The local immune mechanisms responsible for either self-healing or sustained chronic infection are not clear, in the development of E. multilocularis larvae. Here, we developed a suitable experimental model that mimics naturally infected livers, according to the parasite load. We demonstrated that local cellular immunity and fibrogenesis are actually protective and fully able to limit metacestode growth in the liver of low or medium dose-infected mice (LDG or MDG), or even to clear it, while impairment of cellular immunity is followed by a more rapid and severe course of the disease in high dose-infected mice (HDG). And recruitment and/ or proliferation of memory T cells (including CD4 Tem, CD8 Tcm and CD8 Tem) and imbalance of T1/T2/T17/Treg-type T cells in liver were not only associated with clearance of the parasite infection in LDG, but also with increased hepatic injury in HDG; in particular the dual role of CD8 T cells depending on the parasite load and the various stages of metacestode growth. Besides, we first demonstrate the association between LAG3- or 2B4-expressing T cells exhaustion and HD inocula in late stages. Our quantitative experimental model appears fully appropriate to study immunomodulation as a therapeutic strategy for patients with Alveolar Echinococcosis.
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