ArticleScientific reports2017
The parathyroid hormone regulates skin tumour susceptibility in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Targeting PAK1 is effective against cutaneous squamous cell carcinoma in a syngenic mouse model.Cancer science · 2024Article
- Article
- Correlation of Carotid Artery Intima-Media Thickness with Calcium and Phosphorus Metabolism, Parathyroid Hormone, Microinflammatory State, and Cardiovascular Disease.BioMed research international · 2022Article
- A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes.Experimental animals · 2021Article
- Review
- Genetic modifiers of rodent animal models: the role in cataractogenesis.Experimental animals · 2019Review
- Mapping of new skin tumor susceptibility loci by a phenotype-driven congenic approach.Oncology letters · 2018Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Sub-congenic mapping localized Parathyroid hormone (Pth) in Stmm1b. Here, we report that serum intact-PTH (iPTH) and a genetic polymorphism in Pth are important for skin tumour resistance. We identified higher iPTH levels in sera from cancer-resistant MSM/Ms mice compared with susceptible FVB/NJ mice. Therefore, we performed skin carcinogenesis experiments with MSM-BAC transgenic mice (Pth
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