ArticleScientific reports2017
Elevated UMOD methylation level in peripheral blood is associated with gout risk.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Childhood obesity and DNA methylation in an epigenome-wide association study: findings from the Hokkaido Birth Cohort.Clinical epigenetics · 2025Article
- Advances in Traditional Chinese Medicine for Modulating DNA Methylation in the Treatment of Inflammatory Diseases.International journal of molecular sciences · 2025Review
- Epigenetic programming reshapes innate immune memory: decoding the molecular imprint of gouty inflammation.Frontiers in pharmacology · 2025Review
- Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study.Signal transduction and targeted therapy · 2023Review
- Hypomethylation of the opioid receptor delta 1 gene combined with high opioid receptor delta 1 protein levels indicates increased risk of gout.Journal of clinical laboratory analysis · 2022Article
- Susceptibility genes of hyperuricemia and gout.Hereditas · 2022Review
- Exploring RNA modifications, editing, and splicing changes in hyperuricemia and gout.Frontiers in medicine · 2022Article
- IL10 hypomethylation is associated with the risk of gastric cancer.Oncology letters · 2021Article
- FANCF hypomethylation is associated with colorectal cancer in Han Chinese.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Significant association between DHFR promoter methylation and ischemic stroke in a Chinese hypertensive population.Journal of clinical laboratory analysis · 2020Article
- Significant association ofOncology letters · 2019Article
- Association of BAX hypermethylation with coronary heart disease is specific to individuals aged over 70.Medicine · 2019Article
- Endothelial PAS domain protein 1 gene hypomethylation is associated with colorectal cancer in Han Chinese.Experimental and therapeutic medicine · 2018Article
- Significant association of PRMT6 hypomethylation with colorectal cancer.Journal of clinical laboratory analysis · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uromodulin (UMOD) encodes an uromodulin glycoprotein, and its mutation results in uromodulin glycoprotein dysfunction and the occurrence of gout. The aim of our study was to assess whether UMOD methylation could predict the risk of gout. A total of 89 sporadic gout cases and 103 age and gender-matched healthy controls were recruited in this study. UMOD methylation level was determined by quantitative methylation-specific PCR (qMSP) in peripheral blood, and the percentage of methylated reference (PMR) was described to represent the methylation level. Our results showed that UMOD methylation was significantly higher in gout cases than controls (median: 1.45 versus 0.75, P < 0.001). The area under curve (AUC) of UMOD methylation in gout was 0.764 (P = 2.90E-10) with a sensitivity of 65.2% and a specificity of 88.3%. UMOD methylation level was shown to be significantly correlated with the serum level of uric acid (UA) (r = -0.208, P = 0.035). Besides, the luciferase reporter assay showed that UMOD CpG island region was able to upregulate gene expression (fold change = 2, P = 0.004). In conclusion, UMOD methylation assessment might be used to predict the occurrence of gout.
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